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2022-01-18
AbstractAlthough radiotherapy is an important clinical option available for colorectal cancer CRC, its use is restricted due to low radiosensitivity of CRC and high toxicity to surrounding normal tissues. The purpose of this study is to investigate the molecular mechanism by which CRC is not sensitive to radiation and ...
G Tan, Cj Lin, Cy Huang, et al.
Source: Cancer Letters
  IF  :   
2022-01-18
AbstractTanshinone IIA TAN2A is a major active ingredient of Salvia miltiorrhiza used in traditional Chinese medicine and tanshinone 20 TAN20 is a derivative of TAN2A. In this study, we examined the effects of TAN2A and TAN20 on adipogenesis, lipid metabolism, and thermogenesis. Our experiments showed that both TAN2A a...
L Ma, Zw Zhao, Xm Guo, et al.
Source: Molecular and Cellular Endocrinology
  IF  :   
2021-12-31
AbstractBackgroundDiabetic individuals have increased circulating inflammatory mediators which are implicated as underlying causes of neuroinflammation and memory deficits. Tonicity-responsive enhancer-binding protein TonEBP promotes diabetic neuroinflammation. However, the precise role of TonEBP in the diabetic brain ...
E A Jeong, J Lee, H J Shin, et al.
Source: Journal of Neuroinflammation
  IF  :   
2021-12-31
AbstractIgA nephropathy IgAN, membranous nephropathy MN, and lupus nephritis LN represent important causes of chronic kidney disease. They belong to the immune-mediated glomerulonephritis GNs, and have distinct pathogenesis, distinct clinical courses, and variable responses to treatment. Therefore, specific diagnostic ...
N Krata, B Foroncewicz, R Zagożdżon, et al.
Source: Archivum Immunologiae et Therapiae Experimentalis
  IF  :   
2021-12-30
AbstractRadiation enteritis is the most common complication of radiotherapy in patients with pelvic malignancies. Thus, the radioprotective activity of the total hydro-alcoholic extract BGE and the ethyl acetate soluble fraction EAF of Brownea grandiceps leaves was evaluated against ϒ-radiation-induced enteritis in rat...
D A. Korany, R S. Said, I M. Ayoub, et al.
Source: Biomedicine & Pharmacotherapy
  IF  :   
2021-11-29
AbstractBackgroundThe role of serotonin and its metabolic pathway in proper functioning of the pancreas has not been thoroughly investigated yet in acute pancreatitis AP patients. Tryptophan hydroxylase TPH as the rate-limiting enzyme of serotonin synthesis has been considered for possible associations in various disea...
J Snarska, E Fiedorowicz, D Rozmus, et al.
Source: BMC Gastroenterology
  IF  :   
2021-11-29
AbstractSeptic encephalopathy results from the intense reaction of the immune system to infection. The role of growth hormone GH signaling in maintaining brain function is well established; however, the involvement of the vascular endothelial growth factor receptor-2 VEGFR2 in the potential modulatory effect of GH on s...
D A. Zaky, W M. Eldehna, A M. El Kerdawy, et al.
Source: International Immunopharmacology
  IF  :   
2021-11-29
AbstractWith estrogen regulation of the reproductive system, G-protein-coupled membrane estrogen receptor GPER and estrogen-related receptors ERRs are implicated. Non-canonical receptors can bind estrogens such as environmental and pharmacological chemicals. These compounds induce rapid non-genomic pathways or receptor...
A Galuszka, P Pawlicki, L Pardyak, et al.
Source: Animal Reproduction Science
  IF  :   
2021-10-28
AbstractAimsWe aimed to determine whether resistance training RT regulates renal renin-angiotensin system RAS components and inflammatory mediators in diabetic rats.Main methodsMale Wistar rats 3 months old were randomly assigned into four groups: non-trained NT, trained T, non-trained + diabetes NTD and trained +diabe...
R A Santos, V Guzzoni, K A S Silva, et al.
Source: Life Sciences
  IF  :   
2021-10-28
AbstractLipoprotein lipase LPL is a key player in plasma triglyceride metabolism. Consequently, LPL is regulated by several proteins during synthesis, folding, secretion, and transport to its site of action at the luminal side of capillaries, as well as during the catalytic reaction. Some proteins are well known, while...
O Kovrov, F Landfors, V Saar-Kovrov, et al.
Source: JOURNAL OF LIPID RESEARCH
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