ADAM17 (基因名), Disintegrin and metalloproteinase domain-containing protein 17 (蛋白名), ada17_human.
产品名称:
Human ADAM17/ Disintegrin and metalloproteinase domain-containing protein 17 CLIA Kit
解整合素和金属蛋白酶结构域蛋白17
货号:
U1319h
商标:
EIAab®
监管等级:
别名:
Snake venom-like protease, TNF-alpha convertase, TNF-alpha-converting enzyme, CD156b, ADAM 17, CSVP, TACE
检测方法:
CLIA
实验类型:
Sandwich
检测范围:
39-2500pg/mL
特异性:
Natural and recombinant human Disintegrin and metalloproteinase domain-containing protein 17
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
Neurosciences
通用注释
亚单元:
Interacts with MAD2L1, MAPK14 and MUC1.
功能:
Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2.
亚细胞位置:
Membrane
Single-pass type I membrane protein
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