AHR (基因名), Aryl hydrocarbon receptor (蛋白名), ahr_human.
产品名称:
Human AHR/ Aryl hydrocarbon receptor CLIA Kit
芳烃受体
货号:
U1354h
商标:
EIAab®
监管等级:
别名:
Class E basic helix-loop-helix protein 76, bHLHe76, Ah receptor, BHLHE76
检测方法:
CLIA
实验类型:
Sandwich
检测范围:
39-2500pg/mL
特异性:
Natural and recombinant human Aryl hydrocarbon receptor
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
Cancer
通用注释
亚单元:
Binds MYBBP1A (By similarity). Efficient DNA binding requires dimerization with another bHLH protein. In the nucleus, heterodimer of AHR and ARNT. Interacts with coactivators including SRC-1, RIP140 and NOCA7, and with the corepressor SMRT. Interacts with NEDD8 and IVNS1ABP. Interacts with ARNTL/BMAL1. Interacts with HSP90AB1.
功能:
Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1.
亚细胞位置:
Cytoplasm
Nucleus
Initially cytoplasmic; upon binding with ligand and interaction with a HSP90, it translocates to the nucleus.
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