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NOTCH4 (基因名), Neurogenic locus notch homolog protein 4 (蛋白名), notc4_human.

产品名称:

Human NOTCH4/ Neurogenic locus notch homolog protein 4 CLIA Kit
神经源性位点缺口同系物蛋白4

货号:

U2421h

商标:

EIAab^®

监管等级:

RUO

别名:

Notch 4, INT3

检测方法:

CLIA

实验类型:

Sandwich

检测范围:

39-2500pg/mL

特异性:

Natural and recombinant human Neurogenic locus notch homolog protein 4

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Development Biology

规格 & 价格:

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产品说明书

说明书:

MSDS:

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通用注释

亚单元:

Heterodimer of a C-terminal fragment N(TM) and a N-terminal fragment N(EC) which are probably linked by disulfide bonds (By similarity). Interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH4.

功能:

Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May regulate branching morphogenesis in the developing vascular system.

亚细胞位置:

Notch 4 intracellular domain Nucleus Following proteolytical processing NICD is translocated to the nucleus.

数据库链接

UniGene:

Hs.436100

SMR:

Q99466

STRING:

9606.ENSP00000364163

KEGG:

hsa:4855

MIM:

164951

Pfam:

PF00023

Uniprot:

Q99466

相关产品

Mouse Notch4 ELISA Kit

Mouse Notch4 CLIA Kit

Mouse Notch4 Protein

Mouse Notch4 Polyclonal Antibody

Mouse Notch4 Monoclonal Antibody

序列长度:

2003

序列:

仅供参考，详细请咨询（services@eiaab.com）

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Human NOTCH4/ Neurogenic locus notch homolog protein 4 CLIA Kit 神经源性位点缺口同系物蛋白4

U2421h

Notch 4, INT3

Human NOTCH4/ Neurogenic locus notch homolog protein 4 CLIA Kit
神经源性位点缺口同系物蛋白4