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ABCG2 (基因名), ATP-binding cassette sub-family G member 2 (蛋白名), abcg2_human.
产品名称:

ABCG2 Antibody

货号:

P0960Rb-h

商标:
EIAab®
监管等级:
别名:

Breast cancer resistance protein, CDw338, Mitoxantrone resistance-associated protein, Placenta-specific ATP-binding cassette transporter, Urate exporter, CD338, ABCP, BCRP, BCRP1, MXR

序列号:
Q9UNQ0
反应性:
human
免疫原:
Recombinant human ABCG2 protein ( R0960h )
形态:
Liquid
存储说明:
4℃ for frequent use, -20℃ to -70℃ for 6 months
缓冲液:
0.1M×PBS,50% glycerol,pH7.5
浓度:
200ug/ml
纯化方式:
Immunogen affinity purified
克隆性:
Polyclonal
亚型:
Rabbit IgG
应用:
推荐产品:
研究领域:
Neurosciences
  • Human ABCG2 Polyclonal Antibody
  • Human ABCG2 Polyclonal Antibody
  • Human ABCG2 Polyclonal Antibody
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Human ABCG2 Polyclonal Antibody
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产品说明书
数据表: 下载说明书
MSDS: MSDS


R&D 技术数据
Human ABCG2 Polyclonal Antibody
Mouse mAb against NIH/3T3 was subjected to SDS-PAGE followed by Western Blot with ATP-binding cassette sub-family G member 2antibody at dilution of 1:300
Immunohistochemical analysis of paraffin-embedded human bladder cancer tissues using ABCG2 antibody at a dilution of 1:250.
通用注释


亚单元:
Monomer under reducing conditions, the minimal functional units is a homodimer; disulfide-linked, but the major oligomeric form in plasma membranes is a homotetramer with possibility of higher order oligomerization up to homododecamers.


功能:
High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. Implicated in the efflux of numerous drugs and xenobiotics: mitoxantrone, the photosensitizer pheophorbide, camptothecin, methotrexate, azidothymidine (AZT), and the anthracyclines daunorubicin and doxorubicin.


亚细胞位置:
Cell membrane Multi-pass membrane protein Mitochondrion membrane Multi-pass membrane protein


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