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JAK3 (基因名), Tyrosine-protein kinase JAK3 (蛋白名), jak3_human.
产品名称:

JAK3 Antibody

货号:

P0425Rb-h

商标:
EIAab®
监管等级:
别名:

Janus kinase 3, Leukocyte janus kinase, JAK-3, L-JAK

序列号:
P52333
反应性:
human
免疫原:
Recombinant human JAK3 protein ( R0425h )
形态:
Liquid
存储说明:
4℃ for frequent use, -20℃ to -70℃ for 6 months
缓冲液:
0.1M×PBS,50% glycerol,pH7.5
浓度:
200ug/ml
纯化方式:
Immunogen affinity purified
克隆性:
Polyclonal
亚型:
Rabbit IgG
应用:
推荐产品:
研究领域:
Signal Transduction
Human JAK3 Polyclonal Antibody
规格 & 价格: cart
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Human JAK3 Polyclonal Antibody
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产品说明书
数据表: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
Immunohistochemical analysis of formalin -fixed and paraffm-embedded human breast cancer tissue usmgJAK3 antibody.
通用注释


亚单元:
Interacts with STAM2 and MYO18A (By similarity). Interacts with SHB.


功能:
Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A AND STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. Once activated, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion.


亚细胞位置:
Endomembrane system Peripheral membrane protein Cytoplasm


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