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JUP (基因名), Junction plakoglobin (蛋白名), plak_human.
产品名称:

JUP Antibody

货号:

P15107Rb-h

商标:
EIAab®
监管等级:
别名:

Catenin gamma, Desmoplakin III, Desmoplakin-3, CTNNG, DP3

序列号:
P14923
反应性:
human
免疫原:
Recombinant human JUP protein ( R15107h )
形态:
Liquid
存储说明:
4℃ for frequent use, -20℃ to -70℃ for 6 months
缓冲液:
0.1M×PBS,50% glycerol,pH7.5
浓度:
200ug/ml
纯化方式:
Immunogen affinity purified
克隆性:
Polyclonal
亚型:
Rabbit IgG
应用:
推荐产品:
研究领域:
-
Human JUP Polyclonal Antibody
规格 & 价格: cart
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Human JUP Polyclonal Antibody
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产品说明书
数据表: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
Immunohistochemical analysis of formalin-fixed and paraffin-embedded human breast cancer tissue using JUP antibody
通用注释


亚单元:
Homodimer. Component of an E-cadherin/catenin adhesion complex composed of at least E-cadherin/CDH1 and gamma-catenin/JUP, and possibly alpha-catenin/CTNNA1; the complex is located to adherens junctions. The stable association of CTNNA1 is controversial as CTNNA1 was shown not to bind to F-actin when assembled in the complex. Interacts with MUC1. Interacts with CAV1 (By similarity). Interacts with PTPRJ. Interacts with DSG1. Interacts with DSC1 and DSC2. Interacts with PKP2.


功能:
Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.


亚细胞位置:
Cell junction Adherens junction Cell junction Desmosome Cytoplasm Cytoskeleton Membrane Peripheral membrane protein Cytoplasmic in a soluble and membrane-associated form.


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