首页 > 重组蛋白 > Human BDNF Recombinant Protein

BDNF (基因名), Brain-derived neurotrophic factor (蛋白名), bdnf_human.

产品名称:

Human BDNF/ Brain-derived neurotrophic factor Recombinant Protein
脑源性神经营养因子

货号:

R0011h

商标:

EIAab^®

监管等级:

RUO

别名:

Abrineurin, BDNF

序列号:

P23560

来源:

E.coli

种属:

Human

标签:

His

序列:

129-247aa

预估分子量:

13.09 kDa (monomer)

纯度:

Greater than 98% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

Neurosciences

规格 & 价格:

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Human BDNF Protein

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产品说明书

说明书:

MSDS:

在线询价

数据
文献 ( 1 )
出版物
序列 / 3D
常见问题解答
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R&D 技术数据

The PCR product of human BDNF gene was determined by 1% Agarose stained with EB.

Recombinant human BDNF protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.

基因位点

Cytogenetic band: 11p14.1 by HGNC 11p14.1 by Entrez Gene 11p14.1 by Ensembl

BDNF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

Monomers and homodimers. Binds to NTRK2/TRKB.

功能:

During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.

亚细胞位置:

Secreted

数据库链接

UniGene:

Hs.502182

SMR:

P23560

STRING:

9606.ENSP00000414303

KEGG:

hsa:627

MIM:

113505

Pfam:

PF00243

Uniprot:

P23560

相关产品

Mouse Bdnf ELISA Kit

Rat Bdnf ELISA Kit

Bovine BDNF ELISA Kit

Chicken BDNF ELISA Kit

Pig BDNF ELISA Kit

序列长度:

247

序列:

仅供参考，详细请咨询（services@eiaab.com）

50:

100:

150:

200:

247:

KRHWNSQCRT | TQSYVRALTM | DSKKRIGWRF | IRIDTSCVCT | LTIKRGR

3D 模型:

3D 结构:

免疫原序列:

验证序列:

[1].

"S100B Protein, Brain-Derived Neurotrophic Factor, and Glial Cell Line-Derived Neurotrophic Factor in Human Milk"

R Li, W Xia, Z Zhang, K Wu

From: PloS one

[1].

"Brain-derived neurotrophic factor and obesity in the WAGR syndrome."

(PMID: 18753648)

[2].

"Brain-derived neurotrophic factor ( BDNF) gene: no major impact on antidepressant treatment response."

(PMID: 19236730)

[3].

"The effect of depression, BDNF gene val66met polymorphism and gender on serum BDNF levels."

(PMID: 19589373)

[4].

"Met carriers of BDNF Val66Met genotype show increased N-acetylaspartate concentration in the anterior cingulate cortex."

(PMID: 19683059)

[5].

"Genetic association studies of methamphetamine use disorders: A systematic review and synthesis."

(PMID: 19219857)

[6].

"BDNF val66met influences time to onset of levodopa induced dyskinesia in Parkinson's disease."

(PMID: 18977816)

[7].

"BDNF Val66Met polymorphism is associated with HPA axis reactivity to psychological stress characterized by genotype and gender interactions."

(PMID: 18990498)

[8].

"Changes in gyrification over 4 years in bipolar disorder and their association with the brain-derived neurotrophic factor valine(66) methionine variant."

(PMID: 19167700)

[9].

"Genetic susceptibility to schizophrenia: role of dopaminergic pathway gene polymorphisms."

(PMID: 19207030)

[10].

"Molecular differentiation of schizoaffective disorder from schizophrenia using BDNF haplotypes."

(PMID: 19336781)

[1].

人脑源性神经营养因子(BDNF)重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人脑源性神经营养因子(BDNF)重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人脑源性神经营养因子(BDNF)重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人脑源性神经营养因子(BDNF)重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人脑源性神经营养因子(BDNF)重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人脑源性神经营养因子(BDNF)重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人脑源性神经营养因子(BDNF)重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人脑源性神经营养因子(BDNF)重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

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