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Cd36 (基因名), Platelet glycoprotein 4 (蛋白名), cd36_mouse.
产品名称:

Mouse Cd36/ Platelet glycoprotein 4 Recombinant Protein
血小板膜糖蛋白4

货号:

R0674m

商标:
EIAab®
监管等级:
别名:

Glycoprotein IIIb, PAS IV, PAS-4, Platelet glycoprotein IV, GPIIIB, GPIV, CD36

序列号:
Q08857
来源:
E.coli
种属:
Mouse
标签:
His
序列:
30-439aa
预估分子量:
45.1 kDa (monomer)
纯度:
Greater than 90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Immunology
  • Mouse Cd36 Protein
  • Mouse Cd36 Protein
  • Mouse Cd36 Protein
规格 & 价格: cart
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Mouse Cd36 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
Mouse Cd36 Protein
The PCR product of mouse Cd36 gene was determined by 1% Agarose stained with EB.
Mouse Cd36 Protein
Recombinant mouse Cd36 protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.
通用注释


亚单元:
Interacts with THBS1 and THBS2; the interactions mediate the THBS antiangiogenic activity (By similarity) (PubMed:15748999). Upon interaction with a ligand, such as oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42, rapidly forms a complex with TLR4 and TLR6; the complex is internalized and triggers an inflammatory signal. Through its C-terminus, interacts with PTK2, PXN and LYN, but not with SRC. LYN kinase activity is required for facilitating TLR4-TLR6 heterodimerization and signal initiation (By similarity). Interacts with CD9, CD81, FCER1G, ITGB2 and/or ITGB2; forming a membrane heteromeric complex required for the internalization of CD36 and its ligands (PubMed:23395392).


功能:
(Microbial infection) Acts as an accessory receptor for M.tuberculosis lipoprotein LprA, in conjunction with coreceptors TLR2 and TLR1; the lipoprotein acts as an agonist to modulate antigen presenting cell functions in response to the pathogen (PubMed:19362712). Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and the internalization of particles independently of TLR signaling (PubMed:19864601, PubMed:23395392). Mediates uptake of E.coli and S.aureus but has no effect on uptake of M.fortuitum (PubMed:16020694).


亚细胞位置:
Cell membrane Multi-pass membrane protein Apical cell membrane Membrane raft Golgi apparatus Upon ligand-binding, internalized through dynamin-dependent endocytosis.


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