Rat Akr1b1/ Aldo-keto reductase family 1 member B1 CLIA Kit
醛糖还原

货号:

U2220r

商标:

EIAab^®

监管等级:

RUO

别名:

Aldehyde reductase, Aldose reductase, AR, Akr1b4, Aldr1

检测方法:

CLIA

特异性:

Natural and recombinant rat Aldo-keto reductase family 1 member B1

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Metabolism

规格 & 价格:

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Rat Akr1b1 CLIA Kit

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产品说明书

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通用注释

亚单元:

Monomer.

功能:

Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia. Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal. Catalyzes the reduction of diverse phospholipid aldehydes such as 1-palmitoyl-2-(5-oxovaleroyl)-sn -glycero-3-phosphoethanolamin (POVPC) and related phospholipid aldehydes that are generated from the oxydation of phosphotidylcholine and phosphatdyleethanolamides. Plays a role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls).

亚细胞位置:

Cytoplasm

数据库链接

UniGene:

Rn.107801

SMR:

P07943

STRING:

10116.ENSRNOP00000012879

KEGG:

rno:24192

Pfam: