FGG (基因名), Fibrinogen gamma chain (蛋白名), fibg_human.
产品名称:
Human FGG/ Fibrinogen gamma chain CLIA Kit
纤维蛋白原γ链
货号:
U0067h
商标:
EIAab®
监管等级:
别名:
PRO2061
检测方法:
CLIA
实验类型:
Sandwich
检测范围:
0.195-12.5ng/mL
特异性:
Natural and recombinant human Fibrinogen gamma chain
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
-
通用注释
亚单元:
Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.
功能:
Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.
亚细胞位置:
Secreted
[1].
Gorska-Ciebiada M, Saryusz-Wolska M, Borkowska A, et al.
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