Human MIF/ Macrophage migration inhibitory factor CLIA Kit
巨噬细胞迁移抑制因子

货号:

U0698h

商标:

EIAab^®

监管等级:

RUO

别名:

Glycosylation-inhibiting factor, L-dopachrome isomerase, L-dopachrome tautomerase, Phenylpyruvate tautomerase, GIF, MIF, GLIF, MMIF

检测方法:

CLIA

实验类型:

Sandwich

检测范围:

39-2500pg/mL

特异性:

Natural and recombinant human Macrophage migration inhibitory factor

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Immunology

规格 & 价格:

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Human MIF CLIA Kit

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产品说明书

说明书:

MSDS:

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通用注释

亚单元:

Homotrimer. Interacts with CXCR2 extracellular domain (By similarity). Interacts with the CD74 extracellular domain, COPS5 and BNIPL.

功能:

Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.

亚细胞位置:

Secreted Cytoplasm Does not have a cleavable signal sequence and is secreted via a specialized, non-classical pathway. Secreted by macrophages upon stimulation by bacterial lipopolysaccharide (LPS), or by M.tuberculosis antigens.

数据库链接

UniGene:

Hs.407995

SMR:

P14174

STRING:

9606.ENSP00000215754

KEGG:

hsa:4282

MIM:

153620

Pfam: