Human NAMPT/ Nicotinamide phosphoribosyltransferase CLIA Kit
烟碱转磷酸核糖基酶/内脂素

货号:

U0638h

商标:

EIAab^®

监管等级:

RUO

别名:

Pre-B-cell colony-enhancing factor 1, Visfatin, Pre-B cell-enhancing factor, NAmPRTase, PBEF, PBEF1

检测方法:

CLIA

实验类型:

Sandwich

检测范围:

0.195-12.5ng/mL

特异性:

Natural and recombinant human Nicotinamide phosphoribosyltransferase

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Immunology

规格 & 价格:

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Human NAMPT CLIA Kit

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产品说明书

说明书:

MSDS:

在线询价

数据
文献 ( 2 )
序列 / 3D
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通用注释

亚单元:

Homodimer.

功能:

Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-ARNTL/BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression (By similarity).

亚细胞位置:

Nucleus Cytoplasm Secreted Under non-inflammatory conditions, visfatin predominantly exhibits a granular pattern within the nucleus. Secreted by endothelial cells upon IL-1beta stimulation. Abundantly secreted in milk, reaching 100-fold higher concentrations compared to maternal serum.

数据库链接

UniGene:

Hs.489615

SMR:

P43490

STRING:

9606.ENSP00000222553

KEGG:

hsa:10135

MIM:

608764

Pfam: