AGER (基因名), Advanced glycosylation end product-specific receptor (蛋白名), rage_human.
产品名称:
Human AGER/ Advanced glycosylation end product-specific receptor CLIA Kit
晚期糖基化终末产物受体
货号:
U1956h
商标:
EIAab®
监管等级:
别名:
Receptor for advanced glycosylation end products, RAGE
检测方法:
CLIA
实验类型:
Sandwich
检测范围:
0.78-50pg/mL
特异性:
Natural and recombinant human Advanced glycosylation end product-specific receptor
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
Neurosciences
通用注释
亚单元:
Interacts with S100A1 and APP (By similarity). Interacts with S100B, S100A12 and S100A14. Constitutive homodimer; disulfide-linked.
功能:
Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides.
亚细胞位置:
Isoform 10
Cell membrane
Single-pass type I membrane protein
[1].
Gorska-Ciebiada M, Saryusz-Wolska M, Borkowska A, et al
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