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Nrg1 (基因名), Pro-neuregulin-1, membrane-bound isoform (蛋白名), nrg1_rat.
产品名称:

Rat Nrg1/ Pro-neuregulin-1, membrane-bound isoform ELISA Kit
Pro-neuregulin-1,membrane-boundisoform

货号:

E1866r

商标:
EIAab®
监管等级:
别名:

Pro-NRG1, Ndf

检测方法:
ELISA
实验类型:
Sandwich
检测范围:
0.78-50ng/mL
灵敏度:
0.39ng/mL
特异性:
Natural and recombinant rat Pro-neuregulin-1, membrane-bound isoform
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
实验步骤:
实验步骤
研究领域:
-
Rat Nrg1 ELISA Kit
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产品说明书
数据表: 下载说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


精密度
批内差:已知浓度的3个样本在一个板子内重复检测20次,以评估批内精密度。
批内 CV: ≤5.3%
批间差:已知浓度的3个样本在不同的板子上重复测定5次,以评估测定批间精密度。
批间 CV: ≤9.6%
回收率
回收率:低、中和高浓度的分析物被掺入到血清或者血浆样本中,进行回收实验测定。

Sample Type

Average(%)

Recovery Range(%)

Serum

104

98-110

Plasma

106

100-112

 

 

 

 

线性
线性:给定样本通过梯度稀释,每次稀释的测量值与理论值的比值。

Sample

1:2

1:4

1:8

1:16

serum(n=5)

95-103%

98-108%

81-91%

100-108%

EDTA plasma(n=5)

102-112%

105-115%

98-109%

97-109%

heparin plasma(n=5)

98-107%

 

109-119%

90-102%

84-96%

 

通用注释


亚单元:
The cytoplasmic domain interacts with the LIM domain region of LIMK1 (PubMed:9685409). Forms a ternary complex with ERBB3 and ITGAV:ITGB3 or ITGA6:ITGB4.


功能:
Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Binds to ERBB4 and ERBB3. Acts as a ligand for integrins and binds (via EGF domain) to integrins ITGAV:ITGB3 or ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and ERRB3 are essential for NRG1-ERBB signaling (By similarity). Induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1, and ligand-dependent ERBB4 endocytosis is essential for the NRG1-mediated activation of these kinases in neurons (PubMed:17250808).


亚细胞位置:
Neuregulin-1 Secreted



[1].
Ji Fei Zhang , Fu Sheng Zhao, Geng Wu, Qing Fei Kong, Bo Sun, Jingyan Cao, Yao Zhang, Jing Hua Wang, Jing Zhang, Xu Dong Jin , Hu Lun Li
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