首页 > 单抗 > GDF15 Antibody

GDF15 (基因名), Growth/differentiation factor 15 (蛋白名), gdf15_human.

产品名称:

GDF15 Antibody
生长分化因子15

货号:

M2034Rb

商标:

EIAab^®

监管等级:

RUO

别名:

Macrophage inhibitory cytokine 1, NSAID-activated gene 1 protein, NSAID-regulated gene 1 protein, Placental TGF-beta, Placental bone morphogenetic protein, Prostate differentiation factor, MIC-1, NAG-1, NRG-1, GDF-15, MIC1, PDF, PLAB, PTGFB

反应性:

human,mouse

免疫原:

corresponding to a sequence mapping at the 30-308aa of Q99988

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Monoclonal

亚型:

Mouse IgG

应用:

推荐产品:

Goat Anti-Mouse IgG(H+L) HRP-conjugated Antibody

研究领域:

Cancer

规格 & 价格:

关注

Human GDF15 Monoclonal Antibody

邮箱 *

消息 *

Please 登录.

在线询价

数据
文献 ( 2 )
序列 / 3D
反馈墙 (0)

R&D 技术数据

更多信息，请参阅手册，或联系我们的技术支持: tech@eiaab.com.

通用注释

亚单元:

Homodimer; disulfide-linked (PubMed:29046435). Interacts with GFRAL; ligand of GFRAL which mediates GDF15 internalization and cellular signaling through interaction with RET (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099).

功能:

Regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099, PubMed:23468844, PubMed:29046435). Binds to its receptor, GFRAL, and activates GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099). It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which contitutes part of the 'emergency circuit' that shapes feeding responses to stressful conditions (PubMed:28953886). On hepatocytes, inhibits growth hormone signaling (By similarity).

亚细胞位置:

Secreted

数据库链接

UniGene:

Hs.616962

STRING:

9606.ENSP00000252809

KEGG:

hsa:9518

MIM:

605312

Pfam: