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ANGPT1 (基因名), Angiopoietin-1 (蛋白名), angp1_human.

产品名称:

ANGPT1 Antibody

货号:

P0008Rb-h

商标:

EIAab^®

监管等级:

RUO

别名:

ANG-1, KIAA0003

序列号:

Q15389

反应性:

human

免疫原:

Recombinant human ANGPT1 protein ( R0008h )

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

规格 & 价格:

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Human ANGPT1 Polyclonal Antibody

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产品说明书

数据表:

MSDS:

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R&D 技术数据

IHC-P of ANG1 antibody was diluted 1:500 to detect ANG1 in human lung tissue.

通用注释

亚单元:

Homooligomer. Interacts with TEK/TIE2.

功能:

Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. Mediates blood vessel maturation/stability. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme.

亚细胞位置:

Secreted

数据库链接

UniGene:

Hs.369675

SMR:

Q15389

STRING:

9606.ENSP00000428340

KEGG:

hsa:284

MIM: