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DKK1 (基因名), Dickkopf-related protein 1 (蛋白名), dkk1_human.
产品名称:

DKK1 Antibody

货号:

P0741Rb

商标:
EIAab®
监管等级:
别名:

SK, UNQ492/PRO1008, Dickkopf-1

序列号:
O94907
反应性:
human,mouse,rat
免疫原:
corresponding to a sequence mapping at the 32-266aa of O94907
形态:
Liquid
存储说明:
4℃ for frequent use, -20℃ to -70℃ for 6 months
缓冲液:
0.1M×PBS,50% glycerol,pH7.5
浓度:
200ug/ml
纯化方式:
Immunogen affinity purified
克隆性:
Polyclonal
亚型:
Rabbit IgG
应用:
推荐产品:
研究领域:
Cancer
Human DKK1 Polyclonal Antibody
规格 & 价格: cart
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Human DKK1 Polyclonal Antibody
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产品说明书
数据表: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
IHC testing of FFPE human placenta tissue with DKK1 antibody at 10ug/ml. AP-staining.
通用注释


亚单元:
Interacts with LRP6. Interacts (via the C-termianl Cys-rich domain) with LRP5 (via beta-propeller regions 3 and 4); the interaction, enhanced by MESD and or KREMEN, antagonizes Wnt-mediated signaling.


功能:
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.


亚细胞位置:
Secreted


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