NOS2 (基因名), Nitric oxide synthase, inducible (蛋白名), nos2_human.
产品名称:
NOS2 Antibody
货号:
P0837Rb-h
商标:
EIAab®
监管等级:
别名:
Hepatocyte NOS, Inducible NO synthase, NOS type II, Peptidyl-cysteine S-nitrosylase NOS2, HEP-NOS, Inducible NOS, NOS2A
序列号:
P35228
反应性:
human
免疫原:
corresponding to a sequence mapping at the 685-794aa of P35228
形态:
Liquid
存储说明:
4℃ for frequent use, -20℃ to -70℃ for 6 months
缓冲液:
0.1M×PBS,50% glycerol,pH7.5
浓度:
200ug/ml
纯化方式:
Immunogen affinity purified
克隆性:
Polyclonal
亚型:
Rabbit IgG
应用:
推荐产品:
研究领域:
-
R&D 技术数据
通用注释
亚单元:
Homodimer (PubMed:10409685, PubMed:10074942). Interacts with SLC9A3R1 (PubMed:12080081). Interacts with GAPDH; induced by oxidatively-modified low-densitity lipoprotein (LDL(ox)) (PubMed:25417112). Interacts with S100A8 and S100A9 to form the iNOS-S100A8/9 transnitrosylase complex (PubMed:25417112). Interacts with SPSB1, SPSB2 and SPSB4 (PubMed:21199876). Interacts with ELOC and CUL5 in the presence of SPSB1 or SPSB2 or SPSB4 (PubMed:21199876).
功能:
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body (PubMed:7531687, PubMed:7544004). In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2 (By similarity). As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH on 'Cys-247' implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM (PubMed:25417112). Involved in inflammation, enhances the synthesis of proinflammatory mediators such as IL6 and IL8 (PubMed:19688109).
亚细胞位置:
Cytoplasm
Cytosol
Localizes as discrete foci scattered throughout the cytosol and in the presence of SPSB1 and SPSB4, exhibits a more diffuse cytosolic localization.
[1].
Yun-Feng Ni, Jian-Ke Kuai, Zi-Fan Lu, Guo-Dong Yang, Hai-Yan Fu, Jian Wang, Feng Tian, Xiao-Long Yan, Ya-Chao Zhao, Yun-Jie Wang, and Tao Jiang,
[1].
多克隆抗体NOS2可以申请产品的免费试用装吗?
我们不提供作测试目的的免费样品或试用装样品。如果某种抗体的性能与说明书上的数据说明不同,我们将提供换货或退款服务。如果抗体用于未测试的物种或应用,我们不提供换货或退款服务。EIAab产品的投诉期为6个月,逾期不予受理。
[2].
多克隆抗体NOS2说明书上的信息是及时更新的吗?
说明书包含了我们能获得的关于该产品的最新信息。当我们获得另外的信息时,说明书会实时更新,因此说明书绝不会过时。
[3].
如何选择合适的一抗?
请先确定您要检测的种属和使用的实验方法,然后查找相关产品,根据说明书上描述的“种属和应用”来确定合适的抗体。如果说明书中有明确您要检测的种属和实验方法均经过检测,则您可以放心地购买该产品。
[4].
多克隆抗体NOS2在其他物种或应用中测试过吗?
所有我们测试过抗体的物种和应用都会在说明书上说明。我们获取新信息后,就会立即更新物种和应用。
[5].
如何保存多克隆抗体NOS2?
我们建议始终按照说明书上的方法保存抗体。如果没有按照说明书上的说明保存,我们不能保证抗体的性能。
[6].
如何分装多克隆抗体NOS2?
请根据一次实验的常用量进行分装。每等份不应少于10μl;每等份的量越少,抗体储液浓度受蒸发和管壁吸附的影响越大。
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