SLIT2 (基因名), Slit homolog 2 protein (蛋白名), slit2_human.
产品名称:
SLIT2 Antibody
货号:
P0672Rb
商标:
EIAab®
监管等级:
别名:
Slit-2, SLIL3
序列号:
O94813
反应性:
human,rat
免疫原:
corresponding to a sequence mapping at the 1160-1333aa of O94813
形态:
Liquid
存储说明:
4℃ for frequent use, -20℃ to -70℃ for 6 months
缓冲液:
0.1M×PBS,50% glycerol,pH7.5
浓度:
200ug/ml
纯化方式:
Immunogen affinity purified
克隆性:
Polyclonal
亚型:
Rabbit IgG
应用:
推荐产品:
研究领域:
-
R&D 技术数据
SLIT2 antibody detects SLIT2 protein at cytoplasm in rat brain by immunohistochemical analysis.antibody diluted at 1:200.
通用注释
亚单元:
Interacts with GREM1 (By similarity). Homodimer. Binds ROBO1 and ROBO2 with high affinity.
功能:
Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. In spinal chord development may play a role in guiding commissural axons once they reached the floor plate by modulating the response to netrin. In vitro, silences the attractive effect of NTN1 but not its growth-stimulatory effect and silencing requires the formation of a ROBO1-DCC complex. May be implicated in spinal chord midline post-crossing axon repulsion. In vitro, only commissural axons that crossed the midline responded to SLIT2. In the developing visual system appears to function as repellent for retinal ganglion axons by providing a repulsion that directs these axons along their appropriate paths prior to, and after passage through, the optic chiasm. In vitro, collapses and repels retinal ganglion cell growth cones. Seems to play a role in branching and arborization of CNS sensory axons, and in neuronal cell migration. In vitro, Slit homolog 2 protein N-product, but not Slit homolog 2 protein C-product, repels olfactory bulb (OB) but not dorsal root ganglia (DRG) axons, induces OB growth cones collapse and induces branching of DRG axons. Seems to be involved in regulating leukocyte migration.
亚细胞位置:
Secreted
The C-terminal cleavage protein is more diffusible than the larger N-terminal protein that is more tightly cell associated.
数据库链接
验证序列:
[2].
KHAN Y H, YE L, XIE F, et al.
[1].
多克隆抗体SLIT2可以申请产品的免费试用装吗？
我们不提供作测试目的的免费样品或试用装样品。如果某种抗体的性能与说明书上的数据说明不同，我们将提供换货或退款服务。如果抗体用于未测试的物种或应用，我们不提供换货或退款服务。EIAab产品的投诉期为6个月，逾期不予受理。
[2].
多克隆抗体SLIT2说明书上的信息是及时更新的吗？
说明书包含了我们能获得的关于该产品的最新信息。当我们获得另外的信息时，说明书会实时更新，因此说明书绝不会过时。
[3].
如何选择合适的一抗？
请先确定您要检测的种属和使用的实验方法，然后查找相关产品，根据说明书上描述的“种属和应用”来确定合适的抗体。如果说明书中有明确您要检测的种属和实验方法均经过检测，则您可以放心地购买该产品。
[4].
多克隆抗体SLIT2在其他物种或应用中测试过吗？
所有我们测试过抗体的物种和应用都会在说明书上说明。我们获取新信息后，就会立即更新物种和应用。
[5].
如何保存多克隆抗体SLIT2？
我们建议始终按照说明书上的方法保存抗体。如果没有按照说明书上的说明保存，我们不能保证抗体的性能。
[6].
如何分装多克隆抗体SLIT2？
请根据一次实验的常用量进行分装。每等份不应少于10μl；每等份的量越少，抗体储液浓度受蒸发和管壁吸附的影响越大。
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