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SRSF1 (基因名), Serine/arginine-rich splicing factor 1 (蛋白名), srsf1_human.

产品名称:

SRSF1 Antibody

货号:

P8282Rb-h

商标:

EIAab^®

监管等级:

RUO

别名:

Alternative-splicing factor 1, Splicing factor, arginine/serine-rich 1, pre-mRNA-splicing factor SF2, P33 subunit, ASF-1, OK/SW-cl.3, ASF, SF2, SF2P33, SFRS1

序列号:

Q07955

反应性:

human

免疫原:

corresponding to a sequence mapping at the 2-248aa of Q07955

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

规格 & 价格:

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Human SRSF1 Polyclonal Antibody

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产品说明书

数据表:

MSDS:

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R&D 技术数据

IHC-P staining of human lung cancer tissue using SRSF1 antibody.

通用注释

亚单元:

Consists of two polypeptides of p32 and p33. In vitro, self-associates and binds SRSF2, SNRNP70 and U2AF1 but not U2AF2. Binds SREK1/SFRS12. Interacts with SAFB/SAFB1. Interacts with PSIP1/LEDGF. Interacts with SRPK1. Identified in the spliceosome C complex. Interacts with RSRC1 (via Arg/Ser-rich domain). Interacts with ZRSR2/U2AF1-RS2. Interacts with CCDC55 (via C-terminus). Interacts with SRPK1 and a sliding docking interaction is essential for its sequential and processive phosphorylation by SRPK1. Interacts with NXF1. Interacts with CCNL1, CCNL2 and CDK11B (PubMed:18216018).

功能:

Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'-CGAGGCG-3' motif in vitro. Three copies of the octamer constitute a powerful splicing enhancer in vitro, the ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing. Isoform ASF-2 and isoform ASF-3 act as splicing repressors. May function as export adapter involved in mRNA nuclear export through the TAP/NXF1 pathway.

亚细胞位置:

Cytoplasm Nucleus speckle In nuclear speckles. Shuttles between the nucleus and the cytoplasm.

数据库链接

UniGene:

Hs.68714

SMR:

Q07955

STRING:

9606.ENSP00000258962

KEGG:

hsa:6426

MIM: