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TARDBP (基因名), TAR DNA-binding protein 43 (蛋白名), tadbp_human.

产品名称:

TARDBP Antibody

货号:

P1951Rb

商标:

EIAab^®

监管等级:

RUO

别名:

TDP-43, TDP43

序列号:

Q13148

反应性:

human,rat

免疫原:

Recombinant human TARDBP Protein (R1951h)

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

Neurosciences

规格 & 价格:

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Human TARDBP Polyclonal Antibody

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产品说明书

数据表:

MSDS:

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R&D 技术数据

Human plasma was subjected to SDS-PAGE followed by Western Blot with TDP43 antibody at dilution of 1:400 (Observed molecular weight is about 60kDa)

Immunohistochemical analysis of paraffin-embedded rat brain, using TARDBP antibody at 1:200 dilution.

通用注释

亚单元:

Homodimer. Interacts with BRDT (By similarity). Binds specifically to pyrimidine-rich motifs of TAR DNA and to single stranded TG repeated sequences. Binds to RNA, specifically to UG repeated sequences with a minimun of six contiguous repeats. Interacts with ATNX2; the interaction is RNA-dependent (PubMed:20740007). Interacts with MATR3 (PubMed:24686783). Interacts with UBQLN2 (PubMed:23541532). Interacts with HNRNPA2B1 (PubMed:19429692).

功能:

DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR.

亚细胞位置:

Nucleus In patients with frontotemporal lobar degeneration and amyotrophic lateral sclerosis, it is absent from the nucleus of affected neurons but it is the primary component of cytoplasmic ubiquitin-positive inclusion bodies.

数据库链接

UniGene:

Hs.300624

SMR:

Q13148

STRING:

9606.ENSP00000240185

KEGG:

hsa:23435

MIM:

605078

Pfam: