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PLAT (基因名), Tissue-type plasminogen activator (蛋白名), tpa_human.
产品名称:

PLAT Antibody

货号:

P0525Rb-h

商标:
EIAab®
监管等级:
别名:

t-PA

序列号:
P00750
反应性:
human
免疫原:
corresponding to a sequence mapping at the 311-562aa of P00750
形态:
Liquid
存储说明:
4℃ for frequent use, -20℃ to -70℃ for 6 months
缓冲液:
0.1M×PBS,50% glycerol,pH7.5
浓度:
200ug/ml
纯化方式:
Immunogen affinity purified
克隆性:
Polyclonal
亚型:
Rabbit IgG
应用:
推荐产品:
研究领域:
-
Human PLAT Polyclonal Antibody
规格 & 价格: cart
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Human PLAT Polyclonal Antibody
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产品说明书
数据表: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
Immunohistochemical staining of paraffin embedded human testis tissue using PLAT antibody (primary antibody dilution at: 1:20).
通用注释


亚单元:
Heterodimer of chain A and chain B held by a disulfide bond. Forms a heterodimer with SERPINA5. Binds to fibrin with high affinity. This interaction leads to an increase in the catalytic efficiency of the enzyme between 100-fold and 1000-fold, due to an increase in affinity for plasminogen. Similarly, binding to heparin increases the activation of plasminogen. Binds to annexin A2, cytokeratin-8, fibronectin and laminin. Binds to mannose receptor and the low-density lipoprotein receptor-related protein (LRP1); these proteins are involved in TPA clearance. Yet unidentified interactions on endothelial cells and vascular smooth muscle cells (VSMC) lead to a 100-fold stimulation of plasminogen activation. In addition, binding to VSMC reduces TPA inhibition by PAI-1 by 30-fold. Binds LRP1B; binding is followed by internalization and degradation.


功能:
Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. Plays a direct role in facilitating neuronal migration.


亚细胞位置:
Secreted Extracellular space



[1].
Zeng L. · Liu J. · Wang Y. · Wang L. · Weng S. · Chen S. · Yang G.-Y.
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