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TRIB3 (基因名), Tribbles homolog 3 (蛋白名), trib3_human.
产品名称:

TRIB3 Antibody

货号:

P9844Rb

商标:
EIAab®
监管等级:
别名:

Neuronal cell death-inducible putative kinase, SINK, p65-interacting inhibitor of NF-kappa-B, TRB-3, C20orf97, NIPK, SKIP3, TRB3

序列号:
Q96RU7
反应性:
human,mouse,rat
免疫原:
Recombinant human TRIB3 protein ( R9844h )
形态:
Liquid
存储说明:
4℃ for frequent use, -20℃ to -70℃ for 6 months
缓冲液:
0.1M×PBS,50% glycerol,pH7.5
浓度:
200ug/ml
纯化方式:
Immunogen affinity purified
克隆性:
Polyclonal
亚型:
Rabbit IgG
应用:
推荐产品:
研究领域:
Cancer
Human TRIB3 Polyclonal Antibody
规格 & 价格: cart
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Human TRIB3 Polyclonal Antibody
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产品说明书
数据表: 下载说明书
MSDS: MSDS
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R&D 技术数据
Immunohistochemistry of TRB3 in mouse liver tissue with TRS3 polyclonal antibody at 1:50.
通用注释


亚单元:
Interacts with AKT1, AKT2, ATF4, MAP2K1 and MAP2K7. Interacts with DDIT3/CHOP and inhibits its interaction with EP300/P300. Interacts (via N-terminus) with APOBEC3A. Interacts with APOBEC3C.


功能:
Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activity. Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress. Can inhibit APOBEC3A editing of nuclear DNA.


亚细胞位置:
Nucleus


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