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TXNIP (基因名), Thioredoxin-interacting protein (蛋白名), txnip_human.
产品名称:

TXNIP Antibody

货号:

P1162Rb-h

商标:
EIAab®
监管等级:
别名:

Thioredoxin-binding protein 2, Vitamin D3 up-regulated protein 1, VDUP1

序列号:
Q9H3M7
反应性:
human
免疫原:
corresponding to a sequence mapping at the 1-391aa of Q9H3M7
形态:
Liquid
存储说明:
4℃ for frequent use, -20℃ to -70℃ for 6 months
缓冲液:
0.1M×PBS,50% glycerol,pH7.5
浓度:
200ug/ml
纯化方式:
Immunogen affinity purified
克隆性:
Polyclonal
亚型:
Rabbit IgG
应用:
推荐产品:
研究领域:
Cancer
Human TXNIP Polyclonal Antibody
规格 & 价格: cart
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Human TXNIP Polyclonal Antibody
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产品说明书
数据表: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
Immunohistochemistry-Paraffin: TXNIP Antibody IHC analysis of a formalin fixed and paraffinembedded tissue section of mouse kidney using TXNIP antibody at 1:100 dilution.
通用注释


亚单元:
Homodimer; disulfide-linked. Interacts with TXN/thioredoxin through its redox-active site. Interacts with transcriptional repressors ZBTB16, ZBTB32 and HDAC1. Interacts (via C-terminus) with ITCH (via WW domains). Interacts with DDIT4.


功能:
May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1).


亚细胞位置:
Cytoplasm



[1].
Seok Kyo Seo, Hyo In Yang, Kyung Eun Lee, Hye Yeon Kim, SiHyun Cho, Young Sik Choi and Byung Seok Lee
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