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DUSP1 (基因名), Dual specificity protein phosphatase 1 (蛋白名), dus1_human.
产品名称:

Human DUSP1/ Dual specificity protein phosphatase 1 Recombinant Protein
双重特异性蛋白磷酸酶1

货号:

R9899h

商标:
EIAab®
监管等级:
别名:

Dual specificity protein phosphatase hVH1, Mitogen-activated protein kinase phosphatase 1, Protein-tyrosine phosphatase CL100, MAP kinase phosphatase 1, CL100, MKP1, PTPN10, VH1

序列号:
P28562
来源:
E.coli
种属:
Human
标签:
His
序列:
305-367aa
预估分子量:
6.93 kDa (monomer)
纯度:
Greater than 95% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cancer
  • Human DUSP1 Protein
  • Human DUSP1 Protein
  • Human DUSP1 Protein
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Human DUSP1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
The sequence analysis of human DUSP1 protein including hydrophilcity, hydrophobicity and antigenicity.
Human DUSP1 Protein
Recombinant human DUSP1 protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.
基因位点
Cytogenetic band: 5q35.1 by HGNC 5q35.1 by Entrez Gene 5q35.1 by Ensembl
DUSP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
N/A


功能:
Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle.


亚细胞位置:
Nucleus



[1].
"Isolation and characterization of a human dual specificity protein-tyrosine phosphatase gene."

[2].
"Oxidative stress and heat shock induce a human gene encoding a protein-tyrosine phosphatase."

[3].
"Genetic variants within the MAP kinase signalling network and anti-TNF treatment response in rheumatoid arthritis patients."

[4].
"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study."

[5].
"Genetic variation and antioxidant response gene expression in the bronchial airway epithelium of smokers at risk for lung cancer."

[6].
"Dual-specificity phosphatase 1 as a pharmacogenetic modifier of inhaled steroid response among asthmatic patients."

[7].
"Mitogen-activated protein kinase phosphatase-1 negatively regulates the expression of interleukin-6, interleukin-8, and cyclooxygenase-2 in A549 human lung epithelial cells."

[8].
"Proteasomal inhibition upregulates the endogenous MAPK deactivator MKP-1 in human airway smooth muscle: mechanism of action and effect on cytokine secretion."

[9].
"Angiotensin II signaling via type 2 receptors in a human model of vascular hyporeactivity: implications for hypertension."

[10].
"MKP1 repression is required for the chemosensitizing effects of NF-kappaB and PI3K inhibitors to cisplatin in non-small cell lung cancer."
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