首页 > 重组蛋白 > Human FBLN1 Recombinant Protein

FBLN1 (基因名), Fibulin-1 (蛋白名), fbln1_human.

产品名称:

Human FBLN1/ Fibulin-1 Recombinant Protein
衰老关键蛋白1

货号:

R0136h

商标:

EIAab^®

监管等级:

RUO

别名:

PP213, FIBL-1

序列号:

P23142

来源:

E.coli

种属:

Human

标签:

His

序列:

30-578aa

预估分子量:

60.39 kDa (monomer)

纯度:

Greater than 90% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

Immunology

规格 & 价格:

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Human FBLN1 Protein

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产品说明书

说明书:

MSDS:

在线询价

数据
文献 ( 1 )
出版物
序列 / 3D
常见问题解答
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R&D 技术数据

Recombinant human FBLN1 protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.

基因位点

Cytogenetic band: 22q13.31 by HGNC 22q13.31 by Entrez Gene 22q13.31 by Ensembl

FBLN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

Homomultimerizes and interacts with various extracellular matrix components such as FN1, LAMA1, LAMA2, NID, ACAN, CSPG2 and type IV collagen. Interacts also with APP, NOV, FGB and HPV type 16, HPV type 18, HPV type 31 and BPV type 1 E6 proteins. Interacts with FBLN7.

功能:

Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. Has been implicated in a role in cellular transformation and tumor invasion, it appears to be a tumor suppressor. May play a role in haemostasis and thrombosis owing to its ability to bind fibrinogen and incorporate into clots. Could play a significant role in modulating the neurotrophic activities of APP, particularly soluble APP.

亚细胞位置:

Secreted Extracellular space Extracellular matrix

数据库链接

UniGene:

Hs.24601

STRING:

9606.ENSP00000331544

KEGG:

hsa:2192

MIM:

135820

Pfam:

PF12662

Uniprot:

P23142

相关产品

Mouse Fbln1 ELISA Kit

Chicken FBLN1 ELISA Kit

Mouse Fbln1 CLIA Kit

Chicken FBLN1 CLIA Kit

Mouse Fbln1 Protein

序列长度:

703

序列:

仅供参考，详细请咨询（services@eiaab.com）

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703:

YWF

3D 模型:

3D 结构:

免疫原序列:

验证序列:

[1].

"Fibulin-1 is associated with cardiovascular risk in non-obese, non-diabetic individuals"

K Bergmann, A Mańkowska-Cyl, Marek Kretowicz, et al.

From: Folia Medica Copernicana

[1].

"Elevated expression and altered processing of fibulin-1 protein in human breast cancer."

(PMID: 12644824)

[2].

"Estrogen induction and overexpression of fibulin-1C mRNA in ovarian cancer cells."

(PMID: 11850827)

[3].

"Structural and functional characterization of the human and mouse fibulin-1 gene promoters: role of Sp1 and Sp3."

(PMID: 11829738)

[4].

"The fibulin-1 gene (FBLN1) is disrupted in a t(12;22) associated with a complex type of synpolydactyly."

(PMID: 11836357)

[5].

"Interaction of oncogenic papillomavirus E6 proteins with fibulin-1."

(PMID: 12200142)

[6].

"Estradiol and fibulin-1 inhibit motility of human ovarian- and breast-cancer cells induced by fibronectin."

(PMID: 9466671)

[7].

"Increased immunostaining of fibulin-1, an estrogen-regulated protein in the stroma of human ovarian epithelial tumors."

(PMID: 9811350)

[8].

"Human fibulin-1D: molecular cloning, expression and similarity with S1-5 protein, a new member of the fibulin gene family."

(PMID: 9106159)

[9].

"The self-association and fibronectin-binding sites of fibulin-1 map to calcium-binding epidermal growth factor-like domains."

(PMID: 9278415)

[10].

"Suppression of anchorage-independent growth and matrigel invasion and delayed tumor formation by elevated expression of fibulin-1D in human fibrosarcoma-derived cell lines."

(PMID: 9393974)

[1].

人衰老关键蛋白1(FBLN1)重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人衰老关键蛋白1(FBLN1)重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人衰老关键蛋白1(FBLN1)重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人衰老关键蛋白1(FBLN1)重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人衰老关键蛋白1(FBLN1)重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人衰老关键蛋白1(FBLN1)重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人衰老关键蛋白1(FBLN1)重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人衰老关键蛋白1(FBLN1)重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

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