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FGF23 (基因名), Fibroblast growth factor 23 (蛋白名), fgf23_human.
产品名称:

Human FGF23/ Fibroblast growth factor 23 Recombinant Protein
纤维母细胞生长因子23

货号:

R0746h

商标:
EIAab®
监管等级:
别名:

Phosphatonin, Tumor-derived hypophosphatemia-inducing factor, UNQ3027/PRO9828, FGF-23, HYPF

序列号:
Q9GZV9
来源:
E.coli
种属:
Human
标签:
His
序列:
25-251aa
预估分子量:
24.97 kDa (monomer)
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Signal Transduction
Human FGF23 Protein
规格 & 价格: cart
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Human FGF23 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 12p13.32 by HGNC 12p13.32 by Entrez Gene 12p13.32 by Ensembl
FGF23 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by KL and heparan sulfate glycosaminoglycans that function as coreceptors.


功能:
Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL (By similarity). Acts directly on the parathyroid to decrease PTH secretion (By similarity). Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization.


亚细胞位置:
Secreted Secretion is dependent on O-glycosylation.



[1].
"Identification of a novel fibroblast growth factor, FGF-23, preferentially expressed in the ventrolateral thalamic nucleus of the brain."

[2].
"FGF-23 inhibits renal tubular phosphate transport and is a PHEX substrate."

[3].
"Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score."

[4].
"Infantile hypercalcemia and hypercalciuria: new insights into a vitamin D-dependent mechanism and response to ketoconazole treatment."

[5].
"The fibroblast growth factor 23: a new player in the field of cardiovascular, bone and renal disease."

[6].
"The influence of glomerular filtration rate and age on fibroblast growth factor 23 serum levels in pediatric chronic kidney disease."

[7].
"Early control of PTH and FGF23 in normophosphatemic CKD patients: a new target in CKD-MBD therapy?"

[8].
"A prospective study of fibroblast growth factor-23 in children with chronic kidney disease."

[9].
"Circulating fibroblast growth factor-23 is associated with vascular dysfunction in the community."

[10].
"Fibroblast growth factor 23: a possible cause of left ventricular hypertrophy in hemodialysis patients."
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