首页 > 重组蛋白 > Human HBEGF Recombinant Protein

HBEGF (基因名), Proheparin-binding EGF-like growth factor (蛋白名), hbegf_human.

产品名称:

Human HBEGF/ Proheparin-binding EGF-like growth factor Recombinant Protein
肝素结合性表皮生长因子

货号:

R1479h

商标:

EIAab^®

监管等级:

RUO

别名:

DTR, DTS, HEGFL

序列号:

Q99075

来源:

E.coli

种属:

Human

标签:

His

纯度:

>90% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

规格 & 价格:

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Human HBEGF Protein

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产品说明书

说明书:

MSDS:

在线询价

数据
文献 ( 1 )
出版物
序列 / 3D
常见问题解答
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R&D 技术数据

更多信息，请参阅手册，或联系我们的技术支持: tech@eiaab.com.

基因位点

Cytogenetic band: 5q31.3 by HGNC 5q31.3 by Entrez Gene 5q31.3 by Ensembl

HBEGF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

Interacts with FBLN1 (By similarity). Interacts with EGFR and ERBB4.

功能:

Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.

亚细胞位置:

Proheparin-binding EGF-like growth factor Cell membrane Single-pass type I membrane protein

数据库链接

UniGene:

Hs.592942

SMR:

Q99075

STRING:

9606.ENSP00000230990

KEGG:

hsa:1839

MIM:

126150

Pfam:

PF00008

Uniprot:

Q99075

相关产品

Mouse Hbegf ELISA Kit

Rat Hbegf ELISA Kit

Chicken HBEGF ELISA Kit

Pig HBEGF ELISA Kit

Mouse Hbegf CLIA Kit

序列长度:

208

序列:

仅供参考，详细请咨询（services@eiaab.com）

50:

100:

150:

200:

208:

KLGMTNSH

3D 模型:

3D 结构:

免疫原序列:

验证序列:

[1].

"ANNALS EXPRESS: Annexin A2 and its Downstream IL-6 and HB-EGF as Secretory Biomarkers in the Differential Diagnosis of Her-2 Negative Breast Cancer"

Shetty P, Patil V S, Mohan R, et al.

From: Annals of Clinical Biochemistry: An international journal of biochemistry and laboratory medicine

[1].

"Activation of HER4 by heparin-binding EGF-like growth factor stimulates chemotaxis but not proliferation."

(PMID: 9135143)

[2].

"Diphtheria toxin binds to the epidermal growth factor (EGF)-like domain of human heparin-binding EGF-like growth factor/diphtheria toxin receptor and inhibits specifically its mitogenic activity."

(PMID: 7836353)

[3].

"Structure of heparin-binding EGF-like growth factor. Multiple forms, primary structure, and glycosylation of the mature protein."

(PMID: 1556128)

[4].

"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study."

(PMID: 20628086)

[5].

"L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms."

(PMID: 20424473)

[6].

"Decreased expression of heparin-binding epidermal growth factor-like growth factor as a newly identified pathogenic mechanism of antiphospholipid-mediated defective placentation."

(PMID: 20131286)

[7].

"Function-specific intracellular signaling pathways downstream of heparin-binding EGF-like growth factor utilized by human trophoblasts."

(PMID: 20130271)

[8].

"A three-gene signature for outcome in soft tissue sarcoma."

(PMID: 19671876)

[9].

"HB-EGF-induced VEGF production and eNOS activation depend on both PI3 kinase and MAP kinase in HaCaT cells."

(PMID: 19559571)

[10].

"Heparin-binding EGF-like growth factor is a potent dilator of terminal mesenteric arterioles."

(PMID: 19389413)

[1].

人肝素结合性表皮生长因子(HBEGF)重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人肝素结合性表皮生长因子(HBEGF)重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人肝素结合性表皮生长因子(HBEGF)重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人肝素结合性表皮生长因子(HBEGF)重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人肝素结合性表皮生长因子(HBEGF)重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人肝素结合性表皮生长因子(HBEGF)重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人肝素结合性表皮生长因子(HBEGF)重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人肝素结合性表皮生长因子(HBEGF)重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

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