首页 > 重组蛋白 > Human LAIR1 Recombinant Protein

LAIR1 (基因名), Leukocyte-associated immunoglobulin-like receptor 1 (蛋白名), lair1_human.

产品名称:

Human LAIR1/ Leukocyte-associated immunoglobulin-like receptor 1 Recombinant Protein
白细胞相关免疫球蛋白样受体1

货号:

R9027h

商标:

EIAab^®

监管等级:

RUO

别名:

CD305, LAIR-1, CD305

序列号:

Q6GTX8

来源:

E.coli

种属:

Human

标签:

His

纯度:

>90% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

Immunology

规格 & 价格:

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Human LAIR1 Protein

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产品说明书

说明书:

MSDS:

在线询价

数据
文献 ( 1 )
出版物
序列 / 3D
常见问题解答
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R&D 技术数据

更多信息，请参阅手册，或联系我们的技术支持: tech@eiaab.com.

基因位点

Cytogenetic band: 19q13.42 by HGNC 19q13.42 by Entrez Gene 19q13.42 by Ensembl

LAIR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

Interacts with SH2 domains of tyrosine-protein phosphatases PTPN6 and PTPN11. The interaction with PTPN6 is constitutive. Interacts with the SH2 domain of CSK. Binds with high affinity to extracellular matrix collagens, the interaction is functionally important.

功能:

Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells.

亚细胞位置:

Cell membrane Single-pass type I membrane protein

数据库链接

UniGene:

Hs.572535

SMR:

Q6GTX8

STRING:

9606.ENSP00000375622

KEGG:

hsa:3903

MIM:

602992

Pfam:

PF13895

Uniprot:

Q6GTX8

相关产品

Mouse Lair1 ELISA Kit

序列长度:

287

序列:

仅供参考，详细请咨询（services@eiaab.com）

50:

100:

150:

200:

250:

287:

YAQLDHWALT | QRTARAVSPQ | STKPMAESIT | YAAVARH

3D 模型:

3D 结构:

免疫原序列:

验证序列:

[1].

"白细胞相关免疫球蛋白样受体-1 在免疫性血小板减少症患儿中的表达"

黄美玲, 李长钢, 王国兵, et al.

From: 中国当代儿科杂志

[1].

"LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes."

(PMID: 9285412)

[2].

"Crystal structure and collagen-binding site of immune inhibitory receptor LAIR-1: unexpected implications for collagen binding by platelet receptor GPVI."

(PMID: 20007810)

[3].

"Inhibitory receptors CD85j, LAIR-1, and CD152 down-regulate immunoglobulin and cytokine production by human B lymphocytes."

(PMID: 15939744)

[4].

"The inhibitory leukocyte-associated Ig-like receptor-1 (LAIR-1) is expressed at high levels by human naive T cells and inhibits TCR mediated activation."

(PMID: 15950745)

[5].

"Mechanisms of hypergammaglobulinemia and impaired antigen-specific humoral immunity in HIV-1 infection."

(PMID: 14604962)

[6].

"Differential contribution of the immunoreceptor tyrosine-based inhibitory motifs of human leukocyte-associated Ig-like receptor-1 to inhibitory function and phosphatase recruitment."

(PMID: 14565933)

[7].

"Chronic active Epstein-Barr virus infection associated with low expression of leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) on natural killer cells."

(PMID: 12757266)

[8].

"Constitutive association of SHP-1 with leukocyte-associated Ig-like receptor-1 in human T cells."

(PMID: 11160222)

[9].

"Engagement of the leukocyte-associated Ig-like receptor-1 induces programmed cell death and prevents NF-kappaB nuclear translocation in human myeloid leukemias."

(PMID: 11069054)

[10].

"Identification and characterization of leukocyte-associated Ig-like receptor-1 as a major anchor protein of tyrosine phosphatase SHP-1 in hematopoietic cells."

(PMID: 10764762)

[1].

人白细胞相关免疫球蛋白样受体1(LAIR1)重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人白细胞相关免疫球蛋白样受体1(LAIR1)重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人白细胞相关免疫球蛋白样受体1(LAIR1)重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人白细胞相关免疫球蛋白样受体1(LAIR1)重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人白细胞相关免疫球蛋白样受体1(LAIR1)重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人白细胞相关免疫球蛋白样受体1(LAIR1)重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人白细胞相关免疫球蛋白样受体1(LAIR1)重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人白细胞相关免疫球蛋白样受体1(LAIR1)重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

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