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PFN1 (基因名), Profilin-1 (蛋白名), prof1_human.
产品名称:

Human PFN1/ Profilin-1 Recombinant Protein
抑制蛋白1

货号:

R2122h

商标:
EIAab®
监管等级:
别名:

Epididymis tissue protein Li 184a, Profilin I

序列号:
P07737
来源:
E.coli
种属:
Human
标签:
His
序列:
Recombinant protein
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cancer
Human PFN1 Protein
规格 & 价格: cart
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Human PFN1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 17p13.2 by HGNC 17p13.2 by Entrez Gene 17p13.2 by Ensembl
PFN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio. Found in a complex with XPO6, Ran, ACTB and PFN1. Interacts with VASP. Interacts with HTT.


功能:
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR.


亚细胞位置:
Cytoplasm Cytoskeleton



[1].
"Distinct biochemical characteristics of the two human profilin isoforms."

[2].
"Characterization of the three-dimensional solution structure of human profilin: 1H, 13C, and 15N NMR assignments and global folding pattern."

[3].
"Human profilin. Molecular cloning, sequence comparison, and chromosomal analysis."

[4].
"Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosis."

[5].
"Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins."

[6].
"Profilin-1 overexpression inhibits proliferation of MDA-MB-231 breast cancer cells partly through p27kip1 upregulation."

[7].
"Incompatibility with formin Cdc12p prevents human profilin from substituting for fission yeast profilin: insights from crystal structures of fission yeast profilin."

[8].
"Loss of profilin-1 expression enhances breast cancer cell motility by Ena/VASP proteins."

[9].
"Profilin-1 overexpression restores adherens junctions in MDA-MB-231 breast cancer cells in R-cadherin-dependent manner."

[10].
"Both actin and polyproline interactions of profilin-1 are required for migration, invasion and capillary morphogenesis of vascular endothelial cells."
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