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SOD1 (基因名), Superoxide dismutase [Cu-Zn] (蛋白名), sodc_human.
产品名称:

Human SOD1/ Superoxide dismutase [Cu-Zn] Recombinant Protein
超氧化物歧化

货号:

R0596h

商标:
EIAab®
监管等级:
别名:

Superoxide dismutase 1, hSod1

序列号:
P00441
来源:
E.coli
种属:
Human
标签:
His
序列:
1-154aa
预估分子量:
16.94 kDa (monomer)
纯度:
Greater than 95% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Neurosciences
  • Human SOD1 Protein
  • Human SOD1 Protein
  • Human SOD1 Protein
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Human SOD1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
The sequence analysis of human SOD1 protein including hydrophilcity, hydrophobicity and antigenicity.
Human SOD1 Protein
Recombinant human SOD1 protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.
基因位点
Cytogenetic band: 21q22.11 by HGNC 21q22.11 by Entrez Gene 21q22.11 by Ensembl
SOD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Homodimer; non-disulfide linked. Homodimerization may take place via the ditryptophan cross-link at Trp-33. The pathogenic variants ALS1 Arg-38, Arg-47, Arg-86 and Ala-94 interact with RNF19A, whereas wild-type protein does not. The pathogenic variants ALS1 Arg-86 and Ala-94 interact with MARCH5, whereas wild-type protein does not.


功能:
Destroys radicals which are normally produced within the cells and which are toxic to biological systems.


亚细胞位置:
Cytoplasm Mitochondrion Nucleus Predominantly cytoplasmic; the pathogenic variants ALS1 Arg-86 and Ala-94 gradually aggregates and accumulates in mitochondria.



[1].
"Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis."

[2].
"DNA sequence analysis of the conserved region around the SOD1 gene locus in recessively inherited ALS."

[3].
"Age and founder effect of SOD1 A4V mutation causing ALS."

[4].
"Diffusion tensor imaging in sporadic and familial (D90A SOD1) forms of amyotrophic lateral sclerosis."

[5].
"Further evidence that D90A-SOD1 mutation is recessively inherited in ALS patients in Italy."
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