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SOST (基因名), Sclerostin (蛋白名), sost_human.
产品名称:

Human SOST/ Sclerostin Recombinant Protein
硬化蛋白

货号:

R1713h

商标:
EIAab®
监管等级:
别名:

UNQ2976/PRO7455/PRO7476

序列号:
Q9BQB4
来源:
E.coli
种属:
Human
标签:
His
序列:
Recombinant protein
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cancer
Human SOST Protein
规格 & 价格: cart
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Human SOST Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 17q21.31 by HGNC 17q21.31 by Entrez Gene 17q21.31 by Ensembl
SOST Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with LRP4 (via the extracellular domain); the interaction facilitates the inhibition of Wnt signaling. Interacts with LRP5 (via the first two YWTD-EGF repeat domains); the interaction inhibits Wnt-mediated signaling. Interacts with LRP6.


功能:
Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.


亚细胞位置:
Secreted Extracellular space Extracellular matrix



[1].
"Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein."

[2].
"Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)."

[3].
"Characterization of the structural features and interactions of sclerostin: molecular insight into a key regulator of Wnt-mediated bone formation."

[4].
"The -9247 T/C polymorphism in the SOST upstream regulatory region that potentially affects C/EBPalpha and FOXA1 binding is associated with osteoporosis."

[5].
"Analysis of association of LRP5, LRP6, SOST, DKK1, and CTNNB1 genes with bone mineral density in a Slovenian population."

[6].
"Polymorphisms in the sclerosteosis/van Buchem disease gene (SOST) region are associated with bone-mineral density in elderly whites."

[7].
"Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem disease."

[8].
"Lack of association between the SOST gene and bone mineral density in perimenopausal women: analysis of five polymorphisms."

[9].
"Identification of signal peptide domain SOST mutations in autosomal dominant craniodiaphyseal dysplasia."

[10].
"Bone overgrowth-associated mutations in the LRP4 gene impair sclerostin facilitator function."
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