首页 > 重组蛋白 > Human TNFSF11 Recombinant Protein

TNFSF11 (基因名), Tumor necrosis factor ligand superfamily member 11 (蛋白名), tnf11_human.

产品名称:

Human TNFSF11/ Tumor necrosis factor ligand superfamily member 11 Recombinant Protein
肿瘤坏死因子配体超家族成员11

货号:

R0855h

商标:

EIAab^®

监管等级:

RUO

别名:

Osteoclast differentiation factor, Osteoprotegerin ligand, Receptor activator of nuclear factor kappa-B ligand, TNF-related activation-induced cytokine, ODF, OPGL, RANKL, TRANCE, CD254, OPGL, RANKL, TRANCE

序列号:

O14788

来源:

E.coli

种属:

Human

标签:

His

序列:

77-194aa

预估分子量:

12.98 kDa (monomer)

纯度:

Greater than 95% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

Immunology

规格 & 价格:

关注

Human TNFSF11 Protein

邮箱 *

消息 *

Please 登录.

产品说明书

说明书:

MSDS:

在线询价

数据
文献 ( 4 )
出版物
序列 / 3D
常见问题解答
反馈墙 (0)

R&D 技术数据

The sequence analysis of human TNFSF11 protein including hydrophilcity, hydrophobicity and antigenicity.

Recombinant human TNFSF11 protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.

基因位点

Cytogenetic band: 13q14 by HGNC 13q14 by Entrez Gene 13q14 by Ensembl

TNFSF11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

Homotrimer (By similarity). Interacts with TNFRSF11B (PubMed:22664871). Interacts with TNFRSF11A. Interacts with FBN1 (via N-terminal domain) in a Ca(+2)-dependent manner (By similarity).

功能:

Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy (PubMed:22664871). Induces osteoclastogenesis by activating multiple signaling pathways in osteoclast precursor cells, chief among which is induction of long lasting oscillations in the intracellular concentration of Ca (2+) resulting in the activation of NFATC1, which translocates to the nucleus and induces osteoclast-specific gene transcription to allow differentiation of osteoclasts. During osteoclast differentiation, in a TMEM64 and ATP2A2-dependent manner induces activation of CREB1 and mitochondrial ROS generation necessary for proper osteoclast generation (By similarity).

亚细胞位置:

Tumor necrosis factor ligand superfamily member 11, soluble form Secreted

数据库链接

UniGene:

Hs.333791

SMR:

O14788

STRING:

9606.ENSP00000239849

KEGG:

hsa:8600

MIM:

259710

Pfam:

PF00229

Uniprot:

O14788

相关产品

Mouse Tnfsf11 ELISA Kit

Rat Tnfsf11 ELISA Kit

Mouse Tnfsf11 CLIA Kit

Rat Tnfsf11 CLIA Kit

Mouse Tnfsf11 Protein

序列长度:

317

序列:

仅供参考，详细请咨询（services@eiaab.com）

50:

100:

150:

200:

250:

300:

322:

SLLD PDQDA | TYFGAFKVRD | ID

3D 模型:

3D 结构:

免疫原序列:

验证序列:

[1].

"Heme oxygenase-1 mediates protective effects on inflammatory, catabolic and senescence responses induced by interleukin-1β in osteoarthritic..."

Victoria Clérigues, Maria Isabel Guillén, Miguel Angel Castejón, Francisco Gomard, Vicente Mirabete, Maria José Alcaraz

From: Biochemical Pharmacology

[2].

"The Inhibitory Effect of Roasted Licorice Extract on Human Metastatic Breast Cancer Cell-Induced Bone Destruction"

Sun Kyoung Lee, Kwang-Kyun Park, Jung Han Yoon Park, Soon Sung Lim, Won-Yoon Chung

From: PhytotherapyReseach

[3].

"The Inhibitory Effect of Roasted Licorice Extract on Human Metastatic Breast Cancer Cell‐Induced Bone Destruction"

SK Lee, KK Park, JHY Park, et al.

From: Phytotherapy Research

[4].

"Isoliquiritigenin inhibits metastatic breast cancer cell-induced receptor activator of nuclear factor kappa-B ligand/osteoprotegerin ratio in human..."

Lee S K, Park K K, Kim K R, et al.

From: Journal of cancer prevention

[1].

"Osteoprotegerin production by breast cancer cells is suppressed by dexamethasone and confers resistance against TRAIL-induced apoptosis."

(PMID: 19544400)

[2].

"PTHrP induces Notch signaling in periodontal ligament cells."

(PMID: 19587161)

[3].

"Reciprocal roles between caffeine and estrogen on bone via differently regulating cAMP/PKA pathway: the possible mechanism for caffeine-induced osteoporosis in women and estrogen's antagonistic effects."

(PMID: 19278793)

[4].

"Phytoestrogen modulation of bone-related cytokines and its impact on cell viability in human prostate cancer cells."

(PMID: 19632246)

[5].

"Increased signaling through p62 in the marrow microenvironment increases myeloma cell growth and osteoclast formation."

(PMID: 19282458)

[6].

"The role of periodontal ligament cells in delayed tooth eruption in patients with cleidocranial dysostosis."

(PMID: 19960292)

[7].

"Inhibition of interleukin-6 receptor directly blocks osteoclast formation in vitro and in vivo."

(PMID: 19714627)

[8].

"[Role of T-cell leukemia translocation-associated gene (TCTA) protein in human osteoclastogenesis]."

(PMID: 20046013)

[9].

"Secondary lymphoid organs: responding to genetic and environmental cues in ontogeny and the immune response."

(PMID: 19661265)

[10].

"Interleukin-17, RANKL, and osteoprotegerin levels in gingival crevicular fluid from smoking and non-smoking patients with chronic periodontitis during initial periodontal treatment."

(PMID: 19656027)

[1].

人肿瘤坏死因子配体超家族成员11(TNFSF11)重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人肿瘤坏死因子配体超家族成员11(TNFSF11)重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人肿瘤坏死因子配体超家族成员11(TNFSF11)重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人肿瘤坏死因子配体超家族成员11(TNFSF11)重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人肿瘤坏死因子配体超家族成员11(TNFSF11)重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人肿瘤坏死因子配体超家族成员11(TNFSF11)重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人肿瘤坏死因子配体超家族成员11(TNFSF11)重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人肿瘤坏死因子配体超家族成员11(TNFSF11)重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

反馈墙

评论数 : 0

所有用户