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TNFRSF1A (基因名), Tumor necrosis factor receptor superfamily member 1A (蛋白名), tnr1a_human.

产品名称:

Human TNFRSF1A/ Tumor necrosis factor receptor superfamily member 1A Recombinant Protein
肿瘤坏死因子受体超家族成员1A

货号:

R0131h

商标:

EIAab^®

监管等级:

RUO

别名:

Tumor necrosis factor receptor 1, Tumor necrosis factor receptor type I, p55, p60, TNF-R1, TNF-RI, CD120a, TNFAR, TNFR1

序列号:

P19438

来源:

E.coli

种属:

Human

标签:

His

序列:

22-211aa

预估分子量:

20.9 kDa (monomer)

纯度:

>90% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

Neurosciences

规格 & 价格:

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Human TNFRSF1A Protein

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产品说明书

说明书:

MSDS:

在线询价

数据
文献 ( 2 )
出版物
序列 / 3D
常见问题解答
反馈墙 (0)

R&D 技术数据

更多信息，请参阅手册，或联系我们的技术支持: tech@eiaab.com.

基因位点

Cytogenetic band: 12p13.31 by HGNC 12p13.31 by Entrez Gene 12p13.31 by Ensembl

TNFRSF1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

Binding of TNF to the extracellular domain leads to homotrimerization. The aggregated death domains provide a novel molecular interface that interacts specifically with the death domain of TRADD. Various TRADD-interacting proteins such as TRAFS, RIPK1 and possibly FADD, are recruited to the complex by their association with TRADD. This complex activates at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. Interacts with BAG4, BRE, FEM1B, GRB2, SQSTM1 and TRPC4AP. Interacts with HCV core protein. Interacts with human cytomegalovirus/HHV-5 protein UL138. Interacts directly with NOL3 (via CARD domain); inhibits TNF-signaling pathway.

功能:

Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.

亚细胞位置:

Isoform 4 Secreted Lacks a Golgi-retention motif, is not membrane bound and therefore is secreted.

数据库链接

UniGene:

Hs.279594

SMR:

P19438

STRING:

9606.ENSP00000162749

KEGG:

hsa:7132

MIM:

142680

Pfam:

PF00531

Uniprot:

P19438

相关产品

Mouse Tnfrsf1a ELISA Kit

Rat Tnfrsf1a ELISA Kit

Bovine TNFRSF1A ELISA Kit

Pig TNFRSF1A ELISA Kit

Mouse Tnfrsf1a CLIA Kit

序列长度:

455

序列:

仅供参考，详细请咨询（services@eiaab.com）

50:

100:

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455:

PSLLR

3D 模型:

3D 结构:

免疫原序列:

验证序列:

[1].

"Increased Serum Concentrations of Circulating Glycocalyx Components in HELLP Syndrome Compared to Healthy Pregnancy: An Observational Study"

Klaus F. Hofmann-Kiefer, D. Chappell, J. Knabl,H.G. Frank, N. Martinoff, P. Conzen, B.F. Becker, M. Rehm

From: Reproductive Sciences

[2].

"Demethylation of tumor necrosis factor-α converting enzyme predicts poor prognosis in acute-on-chronic hepatitis B liver failure"

Wang Z L, Gao S, Li L, et al

From: Clinics and research in hepatology and gastroenterology

[1].

"Determination of genetic predisposition to patent ductus arteriosus in preterm infants."

(PMID: 19336370)

[2].

"Idiopathic recurrent pericarditis refractory to colchicine treatment can reveal tumor necrosis factor receptor-associated periodic syndrome."

(PMID: 20074469)

[3].

"Genetic polymorphisms of tumour necrosis factor receptor superfamily 1A and 1B affect responses to infliximab in Japanese patients with Crohn's disease."

(PMID: 18248655)

[4].

"Approach to genetic analysis in the diagnosis of hereditary autoinflammatory syndromes."

(PMID: 16234278)

[5].

"A TNFR1 genotype with a protective role in familial rheumatoid arthritis."

(PMID: 14872483)

[6].

"Tumour necrosis factor-alpha receptor 1 and 2 polymorphisms in inflammatory bowel disease and their association with response to infliximab."

(PMID: 15274667)

[7].

"Heterogeneity among patients with tumor necrosis factor receptor-associated periodic syndrome phenotypes."

(PMID: 13130484)

[8].

"Tumor necrosis factor receptor-associated periodic syndrome (TRAPS) in a Dutch family: evidence for a TNFRSF1A mutation with reduced penetrance."

(PMID: 11175303)

[9].

"A novel missense mutation (C30S) in the gene encoding tumor necrosis factor receptor 1 linked to autosomal-dominant recurrent fever with localized myositis in a French family."

(PMID: 10902757)

[10].

"Structure of the human TNF receptor 1 (p60) gene (TNFR1) and localization to chromosome 12p13 [corrected]."

(PMID: 1315717)

[1].

人肿瘤坏死因子受体超家族成员1A(TNFRSF1A)重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人肿瘤坏死因子受体超家族成员1A(TNFRSF1A)重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人肿瘤坏死因子受体超家族成员1A(TNFRSF1A)重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人肿瘤坏死因子受体超家族成员1A(TNFRSF1A)重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人肿瘤坏死因子受体超家族成员1A(TNFRSF1A)重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人肿瘤坏死因子受体超家族成员1A(TNFRSF1A)重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人肿瘤坏死因子受体超家族成员1A(TNFRSF1A)重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人肿瘤坏死因子受体超家族成员1A(TNFRSF1A)重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

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