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TNFRSF1B (基因名), Tumor necrosis factor receptor superfamily member 1B (蛋白名), tnr1b_human.
产品名称:

Human TNFRSF1B/ Tumor necrosis factor receptor superfamily member 1B Recombinant Protein
肿瘤坏死因子受体超家族成员1B

货号:

R0132h

商标:
EIAab®
监管等级:
别名:

Tumor necrosis factor receptor 2, Tumor necrosis factor receptor type II, p75, p80 TNF-alpha receptor, TNF-R2, TNF-RII, CD120b, TNFBR, TNFR2

序列号:
P20333
来源:
E.coli
种属:
Human
标签:
His
序列:
23-257aa
预估分子量:
25.85 kDa (monomer)
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Neurosciences
Human TNFRSF1B Protein
规格 & 价格: cart
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Human TNFRSF1B Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 1p36.22 by HGNC 1p36.22 by Entrez Gene 1p36.22 by Ensembl
TNFRSF1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Binds to TRAF2. Interacts with BMX.


功能:
Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.


亚细胞位置:
Tumor necrosis factor-binding protein 2 Secreted



[1].
"Comment: the methionine 196 arginine polymorphism in exon 6 of the TNF receptor 2 gene (TNFRSF1B) is associated with the polycystic ovary syndrome and hyperandrogenism."

[2].
"Association of tumor necrosis factor receptor type II polymorphism 196R with Systemic lupus erythematosus in the Japanese: molecular and functional analysis."

[3].
"New single nucleotide polymorphisms in the coding region of human TNFR2: association with systemic lupus erythematosus."

[4].
"Single nucleotide polymorphisms in TNF-alpha, TNFR2 gene and TNF-alpha production in Asian Indians."

[5].
"Possible association of tumor necrosis factor receptor 2 gene polymorphism with severe hypertension using the extreme discordant phenotype design."

[6].
"Bone structural effects of variation in the TNFRSF1B gene encoding the tumor necrosis factor receptor 2."

[7].
"Association analysis of TNFRSF1B polymorphisms with type 2 diabetes and its related traits in North India."

[8].
"A functional M196R polymorphism of tumour necrosis factor receptor type 2 is associated with systemic lupus erythematosus: a case-control study and a meta-analysis."

[9].
"-238 and +489 TNF-alpha along with TNF-RII gene polymorphisms associate with the diffuse phenotype in patients with Systemic Sclerosis."

[10].
"TNFR2 gene polymorphism in coronary artery disease."
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