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FAS (基因名), Tumor necrosis factor receptor superfamily member 6 (蛋白名), tnr6_human.
产品名称:

Human FAS/ Tumor necrosis factor receptor superfamily member 6 Recombinant Protein
肿瘤坏死因子受体超家族成员6

货号:

R0030h

商标:
EIAab®
监管等级:
别名:

Apo-1 antigen, Apoptosis-mediating surface antigen FAS, FASLG receptor, CD95, APT1, FAS1, TNFRSF6

序列号:
P25445
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Neurosciences
Human FAS Protein
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Human FAS Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 10q23.31 by HGNC 10q23.31 by Entrez Gene 10q23.31 by Ensembl
FAS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Binds DAXX. Interacts with HIPK3. Part of a complex containing HIPK3 and FADD (By similarity). Binds RIPK1 and FAIM2 (PubMed:7538908, PubMed:10535980). Interacts with BRE and FEM1B (PubMed:10542291, PubMed:15465831). Interacts with FADD (PubMed:21109225, PubMed:19118384). Interacts directly (via DED domain) with NOL3 (via CARD domain); inhibits death-inducing signaling complex (DISC) assembly by inhibiting the increase in FAS-FADD binding induced by FAS activation (By similarity). Interacts with CALM (PubMed:24914971).


功能:
Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).


亚细胞位置:
Isoform 6 Secreted



[1].
"Evaluation of functional single nucleotide polymorphisms of different genes coding for the immunoregulatory molecules in patients with monoclonal large granular lymphocyte lymphocytosis."

[2].
"Disparate distribution of 16 candidate single nucleotide polymorphisms among racial and ethnic groups of pediatric heart transplant patients."

[3].
"A death receptor-associated anti-apoptotic protein, BRE, inhibits mitochondrial apoptotic pathway."

[4].
"Lack of replication of association findings in complex disease: an analysis of 15 polymorphisms in prior candidate genes for sporadic Alzheimer's disease."

[5].
"The development of lymphomas in families with autoimmune lymphoproliferative syndrome with germline Fas mutations and defective lymphocyte apoptosis."

[6].
"Autoimmune lymphoproliferative syndrome with defective Fas: genotype influences penetrance."

[7].
"Somatic Fas mutations in non-Hodgkin's lymphoma: association with extranodal disease and autoimmunity."

[8].
"Structural insights into the mechanism of calmodulin binding to death receptors."

[9].
"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study."

[10].
"Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study."
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