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首页  >  重组蛋白  >  Human TNFRSF11B Recombinant Protein
TNFRSF11B (基因名), Tumor necrosis factor receptor superfamily member 11B (蛋白名), tr11b_human.
产品名称:

Human TNFRSF11B/ Tumor necrosis factor receptor superfamily member 11B Recombinant Protein
肿瘤坏死因子受体超家族成员11B/骨保护素

货号:

R0108h

商标:
EIAab®
监管等级:
别名:

Osteoclastogenesis inhibitory factor, Osteoprotegerin, OCIF, OPG

序列号:
O00300
来源:
E.coli
种属:
Human
标签:
His
序列:
22-401aa
预估分子量:
41.8 kDa (monomer)
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Immunology
Human TNFRSF11B Protein
规格 & 价格: cart
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Human TNFRSF11B Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 8q24.12 by HGNC 8q24.12 by Entrez Gene 8q24.12 by Ensembl
TNFRSF11B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Homodimer. Interacts with TNFSF10 and TNFSF11.


功能:
Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.


亚细胞位置:
Secreted



[1].
"[Osteoprotegerin gene polymorphism and therapeutic response to alendronate in postmenopausal women with osteoporosis]."

[2].
"The combinations of polymorphisms in vitamin D receptor, osteoprotegerin and tumour necrosis factor superfamily member 11 genes are associated with bone mineral density."

[3].
"Multiple genetic loci for bone mineral density and fractures."

[4].
"Polymorphisms at the osteoprotegerin and interleukin-6 genes in relation to first-ever stroke."

[5].
"The relationship between four single nucleotide polymorphisms in the promoter region of the osteoprotegerin gene and aortic calcification or coronary artery disease in Koreans."

[6].
"Serum levels of osteoprotegerin and osteoprotegerin polymorphisms in Gaucher disease."

[7].
"Susceptibility to Paget's disease of bone is influenced by a common polymorphic variant of osteoprotegerin."

[8].
"Single nucleotide polymorphisms in the human gene for osteoprotegerin are not related to bone mineral density or fracture in elderly women."

[9].
"A mutation in the gene TNFRSF11B encoding osteoprotegerin causes an idiopathic hyperphosphatasia phenotype."

[10].
"Investigation of the genetic influence of the OPG, VDR (Fok1), and COLIA1 Sp1 polymorphisms on BMD in the Irish population."
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