General AP/ Allopregnanolone CLIA Kit
别孕烯醇酮

货号:

U1963Ge

商标:

EIAab^®

监管等级:

RUO

别名:

3α, 5α-tetrahydroprogesterone, 3α-hydroxy-5α-pregnan-20-one

检测方法:

CLIA

实验类型:

Competitive

检测范围:

3.9-250pg/mL

特异性:

Natural and recombinant general Allopregnanolone

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

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通用注释

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功能:

Allopregnanolone (3α-hydroxy-5α-pregnan-20-one or 3α,5α-tetrahydroprogesterone) is a prototypic neurosteroid present in the blood and also the brain. It is a metabolite of progesterone and potent modulator of GABAA receptors. While allopregnanolone, like other GABAA receptor active neurosteroids such as allotetrahydrodeoxycorticosterone (3α,21-dihydroxy-5α-pregnan-20-one; THDOC), positively modulates all GABAA receptor isoforms, those isoforms containing δ-subunits exhibit greater magnitude potentiation. Allopregnanolone has pharmacological properties similar to other positive modulators of GABAA receptors, including anxiolytic and anticonvulsant activity.

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