ABCA4 (基因名), Retinal-specific phospholipid-transporting ATPase ABCA4 (蛋白名), abca4_human.
产品名称:
Human ABCA4/ Retinal-specific phospholipid-transporting ATPase ABCA4 CLIA Kit
视网膜特异性磷脂转运atp酶ABCA4
货号:
U10399h
商标:
EIAab®
监管等级:
别名:
ATP-binding cassette sub-family A member 4, RIM ABC transporter, Retinal-specific ATP-binding cassette transporter, Stargardt disease protein, RIM protein, ABCR
检测方法:
CLIA
实验类型:
Sandwich
检测范围:
10.9-700pg/mL
特异性:
Natural and recombinant human Retinal-specific phospholipid-transporting ATPase ABCA4
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
登录.
研究领域:
-
通用注释
亚单元:
N/A
功能:
Catalyzes the translocation of specific phospholipids from the extracellular/lumenal to the cytoplasmic leaflet of membrane coupled to the hydrolysis of ATP (PubMed:24097981). Transports preferentially phosphatidylethanolamine (PubMed:24097981). In the visual cycle, acts as an inward-directed retinoid flipase, retinoid substrates imported by ABCA4 from the extracellular or intradiscal (rod) membrane surfaces to the cytoplasmic membrane surface are all-trans-retinaldehyde (ATR) and N-retinyl-phosphatidyl-ethanolamine (NR-PE). Once transported to the cytoplasmic surface, ATR is reduced to vitamin A by trans-retinol dehydrogenase (tRDH) and then transferred to the retinal pigment epithelium (RPE) where it is converted to 11-cis-retinal. May play a role in photoresponse, removing ATR/NR-PE from the extracellular photoreceptor surfaces during bleach recovery.
亚细胞位置:
Membrane
Multi-pass membrane protein
Endoplasmic reticulum
Localized to outer segment disk edges of rods and cones, with around one million copies/photoreceptor.
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