Abhd12 (基因名), Lysophosphatidylserine lipase ABHD12 (蛋白名), abd12_mouse.
产品名称:
Mouse Abhd12/ Lysophosphatidylserine lipase ABHD12 CLIA Kit
货号:
U6236m
商标:
EIAab®
监管等级:
别名:
2-arachidonoylglycerol hydrolase ABHD12, Abhydrolase domain-containing protein 12, Monoacylglycerol lipase ABHD12, Oxidized phosphatidylserine lipase ABHD12
检测方法:
CLIA
特异性:
Natural and recombinant mouse Lysophosphatidylserine lipase ABHD12
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
-
通用注释
亚单元:
N/A
功能:
Lysophosphatidylserine (LPS) lipase that mediates the hydrolysis of lysophosphatidylserine, a class of signaling lipids that regulates immunological and neurological processes (PubMed:23297193, PubMed:25580854, PubMed:30420694). Represents a major lysophosphatidylserine lipase in the brain, thereby playing a key role in the central nervous system (PubMed:23297193). Also able to hydrolyze oxidized phosphatidylserine; oxidized phosphatidylserine is produced in response to severe inflammatory stress and constitutes a proapoptotic 'eat me' signal (PubMed:30643283). Also has monoacylglycerol (MAG) lipase activity: hydrolyzes 2-arachidonoylglycerol (2-AG), thereby acting as a regulator of endocannabinoid signaling pathways (PubMed:18096503). Has a strong preference for very-long-chain lipid substrates; substrate specificity is likely due to improved catalysis and not improved substrate binding (PubMed:30237167).
亚细胞位置:
Endoplasmic reticulum membrane
Single-pass membrane protein
Mitochondrion
数据库链接
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