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Adam17 (基因名), Disintegrin and metalloproteinase domain-containing protein 17 (蛋白名), ada17_mouse.

产品名称:

Mouse Adam17/ Disintegrin and metalloproteinase domain-containing protein 17 CLIA Kit
解整合素和金属蛋白酶结构域蛋白17

货号:

U1319m

商标:

EIAab^®

监管等级:

RUO

别名:

TNF-alpha convertase, TNF-alpha-converting enzyme, CD156b, ADAM 17, Tace

检测方法:

CLIA

特异性:

Natural and recombinant mouse Disintegrin and metalloproteinase domain-containing protein 17

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Neurosciences

规格 & 价格:

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通用注释

亚单元:

Interacts with MAD2L1, MAPK14 and MUC1.

功能:

Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Plays a role in the proteolytic processing of ACE2 (By similarity). Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called notch extracellular truncation (NEXT).

亚细胞位置:

Isoform Short Secreted

数据库链接

UniGene:

Mm.27681

SMR:

Q9Z0F8

STRING:

10090.ENSMUSP00000067953

KEGG:

mmu:11491

Pfam: