Bovine ADIPOQ/ Adiponectin CLIA Kit
脂联素

货号:

U0605b

商标:

EIAab^®

监管等级:

RUO

别名:

30 kDa adipocyte complement-related protein, Adipocyte complement-related 30 kDa protein, Adipocyte, C1q and collagen domain-containing protein, Adipose most abundant gene transcript 1 protein, ACRP30, apM-1, ACRP30, APM1

检测方法:

CLIA

实验类型:

Sandwich

检测范围:

0.39-25ng/mL

特异性:

Natural and recombinant bovine Adiponectin

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

规格 & 价格:

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Bovine ADIPOQ CLIA Kit

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产品说明书

说明书:

MSDS:

在线询价

数据
文献
序列 / 3D
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通用注释

亚单元:

Homomultimer. Forms trimers, hexamers and 12- to 18-mers. The trimers (low molecular weight complexes / LMW) are assembled via non-covalent interactions of the collagen-like domains in a triple helix and hydrophobic interactions within the globular C1q domain. Several trimers can associate to form disulfide-linked hexamers (middle molecular weight complexes / MMW) and larger complexes (higher molecular weight / HMW). The HMW-complex assembly may rely additionally on lysine hydroxylation and glycosylation. LMW, MMW and HMW complexes bind to HBEGF, MMW and HMW complexes bind to PDGFB, and HMW complex binds to FGF2. Interacts with CTRP9 via the C1q domain (heterotrimeric complex).

功能:

Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW.

亚细胞位置:

Secreted

数据库链接

UniGene:

Bt.109637

SMR:

Q3Y5Z3

STRING:

9913.ENSBTAP00000026395

KEGG:

bta:282865

Pfam: