ADRB2 (基因名), Beta-2 adrenergic receptor (蛋白名), adrb2_human.
产品名称:
Human ADRB2/ Beta-2 adrenergic receptor CLIA Kit
β2肾上腺素能受体
货号:
U9974h
商标:
EIAab®
监管等级:
别名:
Beta-2 adrenoreceptor, Beta-2 adrenoceptor, ADRB2R, B2AR
检测方法:
CLIA
特异性:
Natural and recombinant human Beta-2 adrenergic receptor
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
Signal Transduction
通用注释
亚单元:
Binds SLC9A3R1 and GPRASP1. Interacts with ARRB1 and ARRB2. Interacts with SRC, USP20 and USP33. Interacts with VHL; the interaction, which is increased on hydroxylation of ADRB2, ubiquitinates ADRB2 leading to its degradation. Interacts with EGLN3; the interaction hydroxylates ADRB2 facilitating VHL-E3 ligase-mediated ubiquitination. Interacts (via PDZ-binding motif) with SNX27 (via PDZ domain); the interaction is required when endocytosed to prevent degradation in lysosomes and promote recycling to the plasma membrane. Interacts with CNIH4 (PubMed:24405750). Interacts with ARRDC3 (PubMed:20559325, PubMed:25220262).
功能:
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
亚细胞位置:
Cell membrane
Multi-pass membrane protein
Early endosome
Colocalizes with VHL at the cell membrane (PubMed:19584355). Activated receptors are internalized into endosomes prior to their degradation in lysosomes (PubMed:20559325).
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