Rat Adrb2/ Beta-2 adrenergic receptor CLIA Kit
β2肾上腺素能受体

货号:

U9974r

商标:

EIAab^®

监管等级:

RUO

别名:

Beta-2 adrenoreceptor, Beta-2 adrenoceptor, Adrb2r

检测方法:

CLIA

特异性:

Natural and recombinant rat Beta-2 adrenergic receptor

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Signal Transduction

规格 & 价格:

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Rat Adrb2 CLIA Kit

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通用注释

亚单元:

Binds SLC9A3R1 and GPRASP1. Interacts with ARRB1 and ARRB2. Interacts with SRC, USP20 and USP33. Interacts with VHL; the interaction, which is increased on hydroxylation of ADRB2, ubiquitinates ADRB2 leading to its degradation. Interacts with EGLN3; the interaction hydroxylates ADRB2 facilitating VHL-E3 ligase-mediated ubiquitination. Interacts (via PDZ-binding motif) with SNX27 (via PDZ domain); the interaction is required when endocytosed to prevent degradation in lysosomes and promote recycling to the plasma membrane. Interacts with CNIH4. Interacts with ARRDC3.

功能:

Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.

亚细胞位置:

Cell membrane Multi-pass membrane protein Early endosome Colocalizes with VHL on cell membranes. Activated receptors are internalized into endosomes prior to their degradation in lysosomes.

数据库链接

UniGene:

Rn.10206

SMR:

P10608

STRING:

10116.ENSRNOP00000026098

Pfam:

PF00001

Uniprot:

P10608

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