ADGRV1 (基因名), Adhesion G-protein coupled receptor V1 (蛋白名), agrv1_human.
产品名称:
Human ADGRV1/ Adhesion G-protein coupled receptor V1 CLIA Kit
货号:
U12841h
商标:
EIAab®
监管等级:
别名:
G-protein coupled receptor 98, Monogenic audiogenic seizure susceptibility protein 1 homolog, Usher syndrome type-2C protein, Very large G-protein coupled receptor 1, ADGRV1, GPR98, KIAA0686, KIAA1943, MASS1, VLGR1
检测方法:
CLIA
特异性:
Natural and recombinant human Adhesion G-protein coupled receptor V1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
-
通用注释
亚单元:
Forms a heterodimer, consisting of a large extracellular region (alpha subunit) non-covalently linked to a seven-transmembrane moiety (beta subunit) (By similarity). Component of USH2 complex, composed of ADGRV1, PDZD7, USH2A and WHRN. Interacts with USH2A and WHRN (PubMed:16434480). Interacts (via the cytoplasmic region) with PDZD7 (PubMed:20440071). Interacts (via the cytoplasmic region) with MYO7A (via MyTH4-FERM domains) (By similarity).
功能:
Cleaved ADGRV1 beta-subunit couples with G-alpha(i)-proteins, GNAI1/2/3, and constitutively inhibits adenylate cyclase (AC) activity with a stronger effect than full ADGRV1.
亚细胞位置:
Cell membrane
Multi-pass membrane protein
Cell projection
Stereocilium membrane
Photoreceptor inner segment
Localizes at the ankle region of the stereocilia. In photoreceptors, localizes at a plasma membrane microdomain in the apical inner segment that surrounds the connecting cilia called periciliary membrane complex.
数据库链接
验证序列:
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