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Aimp2 (基因名), Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (蛋白名), aimp2_mouse.

产品名称:

Mouse Aimp2/ Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 CLIA Kit
氨酰tRNA合成酶络合作用多功能蛋白2

货号:

U2927m

商标:

EIAab^®

监管等级:

RUO

别名:

Multisynthase complex auxiliary component p38, Protein JTV-1, Jtv1

检测方法:

CLIA

特异性:

Natural and recombinant mouse Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

规格 & 价格:

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通用注释

亚单元:

Component of the aminoacyl-tRNA synthase complex which is comprised of a bifunctional glutamyl-prolyl-tRNA synthase, the monospecific isoleucyl, leucyl, glutaminyl, methionyl, lysyl, arginyl and aspartyl-tRNA synthases, and three auxiliary proteins, EEF1E1/p18, AIMP2/p38 and AIMP1/p43. Binds FUBP1 (via C-terminus). Interacts in both its unphosphorylated and phosphorylated forms with p53/TP53 (via N-terminus) in the nucleus following UV irradiation. Interacts (via N-terminus) with KARS and PARK2/parkin (via first RING-type domain).

功能:

Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor.

亚细胞位置:

Cytoplasm Cytosol Nucleus Following DNA damage, dissociates from the aminoacyl-tRNA synthase complex and translocates from the cytoplasm to the nucleus.

数据库链接

UniGene:

Mm.200499

SMR:

Q8R010

STRING:

10090.ENSMUSP00000031613

KEGG:

mmu:231872

Pfam:

PF16780

Uniprot: