Bovine AKR1A1/ Aldo-keto reductase family 1 member A1 CLIA Kit
醛酮还原酶家族1成员A1

货号:

U14182b

商标:

EIAab^®

监管等级:

RUO

别名:

Alcohol dehydrogenase [NADP(+)], Aldehyde reductase, Glucuronate reductase, Glucuronolactone reductase

检测方法:

CLIA

特异性:

Natural and recombinant bovine Aldo-keto reductase family 1 member A1

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

规格 & 价格:

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Bovine AKR1A1 CLIA Kit

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亚单元:

Monomer.

功能:

Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids, with a preference for negatively charged substrates, such as glucuronate and succinic semialdehyde (By similarity). Plays an important role in ascorbic acid biosynthesis by catalyzing the reduction of D-glucuronic acid and D-glucurono-gamma-lactone (By similarity). Functions as a detoxifiying enzyme by reducing a range of toxic aldehydes. Reduces methylglyoxal and 3-deoxyglucosone, which are present at elevated levels under hyperglycemic conditions and are cytotoxic. Involved also in the detoxification of lipid-derived aldehydes like acrolein (By similarity). Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs (By similarity). Displays no reductase activity towards retinoids (By similarity).

亚细胞位置:

Cytoplasm Cytosol Apical cell membrane

数据库链接

UniGene:

Bt.49266

SMR:

Q3ZCJ2

STRING:

9913.ENSBTAP00000000630

KEGG:

bta:618607

Pfam: