Rat Akt2/ RAC-beta serine/threonine-protein kinase CLIA Kit
RACβ丝氨酸/苏氨酸蛋白激

货号:

U9360r

商标:

EIAab^®

监管等级:

RUO

别名:

Protein kinase Akt-2, Protein kinase B beta, RAC-PK-beta, PKB beta

检测方法:

CLIA

特异性:

Natural and recombinant rat RAC-beta serine/threonine-protein kinase

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Cancer

规格 & 价格:

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Rat Akt2 CLIA Kit

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通用注释

亚单元:

Interacts with BTBD10 (By similarity). Interacts with KCTD20 (By similarity). Interacts (via PH domain) with MTCP1, TCL1A AND TCL1B. Interacts with TRAF6. Interacts (when phosphorylated) with CLIP3, the interaction promotes cell membrane localization (By similarity). Interacts with CLK2 (PubMed:20074525). Interacts with WDFY2 (via WD repeats 1-3).

功能:

One of the few specific substrates of AKT2 identified so far is PITX2. Phosphorylation of PITX2 impairs its association with the CCND1 mRNA-stabilizing complex thus shortening the half-life of CCND1. AKT2 seems also to be the principal isoform responsible of the regulation of glucose uptake. Phosphorylates C2CD5 on 'Ser-197' during insulin-stimulated adipocytes. AKT2 is also specifically involved in skeletal muscle differentiation, one of its substrates in this process being ANKRD2. Phosphorylates CLK2 on 'Thr-343'.

亚细胞位置:

Cytoplasm Nucleus Cell membrane Peripheral membrane protein Early endosome Localizes within both nucleus and cytoplasm of proliferative primary myoblasts and mostly within the nucleus of differentiated primary myoblasts. By virtue of the N-terminal PH domain, is recruited to sites of the plasma membrane containing increased PI(3,4,5)P3 or PI(3,4)P2, cell membrane targeting is also facilitared by interaction with CLIP3. Colocalizes with WDFY2 in early endosomes.

数据库链接

UniGene:

Rn.87066

SMR:

P47197

STRING:

10116.ENSRNOP00000025303

KEGG:

rno:25233

Pfam:

PF00169

Uniprot: