Akr1b1 (基因名), Aldo-keto reductase family 1 member B1 (蛋白名), aldr_rat.
产品名称:
Rat Akr1b1/ Aldo-keto reductase family 1 member B1 CLIA Kit
醛糖还原
货号:
U2220r
商标:
EIAab®
监管等级:
别名:
Aldehyde reductase, Aldose reductase, AR, Akr1b4, Aldr1
检测方法:
CLIA
特异性:
Natural and recombinant rat Aldo-keto reductase family 1 member B1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
Metabolism
通用注释
亚单元:
Monomer.
功能:
Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia. Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal. Catalyzes the reduction of diverse phospholipid aldehydes such as 1-palmitoyl-2-(5-oxovaleroyl)-sn -glycero-3-phosphoethanolamin (POVPC) and related phospholipid aldehydes that are generated from the oxydation of phosphotidylcholine and phosphatdyleethanolamides. Plays a role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls).
亚细胞位置:
Cytoplasm
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